DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4781 and lingo3a

DIOPT Version :9

Sequence 1:NP_611951.1 Gene:CG4781 / 37943 FlyBaseID:FBgn0035043 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_001076323.1 Gene:lingo3a / 567293 ZFINID:ZDB-GENE-060503-54 Length:605 Species:Danio rerio


Alignment Length:464 Identity:119/464 - (25%)
Similarity:178/464 - (38%) Gaps:130/464 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LTFALLLTQLLAAHVARAEVIDAEETDRFCYPESSKNSRRSCECSN--VSASPWGNRALRIDCSY 72
            |:.:.||..|:.|.:...:.. .:..|  |.|.     :|:..|.|  :.:.|.|          
Zfish     7 LSLSGLLVLLITASITHGQSC-PQRCD--CIPH-----QRAVMCQNKRLGSIPGG---------- 53

  Fly    73 KDYKVADLSLLLPLYIDSLDLSWNALDSVPIFTSDSLHQLNLRHNNISQLVSGNFKQLTSLRELY 137
                       :|.....||||.|:|..|             .:|::|.|:        .|.||.
Zfish    54 -----------IPADTRLLDLSCNSLRWV-------------EYNDLSTLL--------RLEELD 86

  Fly   138 LGWNSIGKLESGSFDGLPHLQVLDLAHNNLHLLPGHLFAPLLVLGTLDISWNRRFNESGGDLYTG 202
            |..|.|..||..:|..|.:|:||.|..|.|.|:|...|:.|..|.|||:|.|:        |...
Zfish    87 LSENLISVLEPNAFSSLLNLRVLRLRANQLKLVPMGAFSRLTNLTTLDLSGNK--------LVIL 143

  Fly   203 LGVNWK-LSTLRLDACSLNDLHLPVN------APLKELSLRRNQLKRIPTQLPETL-----LRLD 255
            |...:: |..||......|||....|      ..|:||::.|..|..|..|....|     |||.
Zfish   144 LDFTFQDLRNLRNLEVGDNDLVYISNKAFLGLVGLRELTIERCNLTSISGQSLSYLRGLVTLRLR 208

  Fly   256 -ISDNLLEELLPEDTANLTQVRQLFIEDMPVLQRVVANSL------------THVDVLETLSFQN 307
             :|...|||   ::...|..:|.|.|:..|.|:.:..:|.            |::..:.|.:.:|
Zfish   209 YLSIASLEE---QNFRKLGGLRGLEIDHWPFLEYISPHSFQGLNLSWLSITNTNISTVPTGALRN 270

  Fly   308 SRQLSHLDAEAFGPIMTTPTKKRALR------SLSFRGT-----------------MLRTFNSTL 349
            ...|:.|:. ::.||  :..:..|||      .|...||                 :|...|:.|
Zfish   271 LIHLASLNL-SYNPI--SVLESWALRDLVRLKELHLVGTNLISVQPYGLGGLQQIRLLNLSNNGL 332

  Fly   350 API-------FTQLAELDLNGLPLQCDCELVWLKQLPVQTN--GR---CYKPARIRGMLVT---- 398
            ..:       ...|..|.::|.||.|||.|:|:.|.....|  |:   |..|..:||..::    
Zfish   333 VTLEEGSFHSVNTLETLRVDGNPLSCDCRLLWILQRRKTLNFDGKSPVCTAPVEVRGKSLSTFTD 397

  Fly   399 SARGDAFSC 407
            ||..|.|:|
Zfish   398 SALFDHFTC 406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4781NP_611951.1 leucine-rich repeat 90..108 CDD:275380 7/17 (41%)
LRR_8 108..167 CDD:290566 18/58 (31%)
leucine-rich repeat 109..132 CDD:275380 3/22 (14%)
LRR_RI <121..>261 CDD:238064 48/152 (32%)
leucine-rich repeat 133..156 CDD:275380 10/22 (45%)
leucine-rich repeat 157..180 CDD:275380 10/22 (45%)
leucine-rich repeat 181..208 CDD:275380 8/26 (31%)
leucine-rich repeat 230..253 CDD:275380 8/27 (30%)
leucine-rich repeat 254..274 CDD:275380 6/20 (30%)
leucine-rich repeat 275..299 CDD:275380 7/35 (20%)
leucine-rich repeat 300..319 CDD:275380 4/18 (22%)
lingo3aNP_001076323.1 LRRNT 27..60 CDD:214470 9/61 (15%)
LRR <49..357 CDD:227223 90/363 (25%)
leucine-rich repeat 58..81 CDD:275380 10/43 (23%)
leucine-rich repeat 82..105 CDD:275380 10/22 (45%)
leucine-rich repeat 130..153 CDD:275380 9/30 (30%)
leucine-rich repeat 154..177 CDD:275380 6/22 (27%)
leucine-rich repeat 178..201 CDD:275380 8/22 (36%)
leucine-rich repeat 202..225 CDD:275380 8/25 (32%)
leucine-rich repeat 226..249 CDD:275380 6/22 (27%)
leucine-rich repeat 250..273 CDD:275380 3/22 (14%)
leucine-rich repeat 274..297 CDD:275380 7/25 (28%)
leucine-rich repeat 298..321 CDD:275380 3/22 (14%)
leucine-rich repeat 322..342 CDD:275380 3/19 (16%)
PCC 326..>392 CDD:188093 19/65 (29%)
Ig 424..492 CDD:325142
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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