Protein Alignment CG4781 and Lingo4

DIOPT Version :10

• Sequence 1: NP_611951.1
• Gene: CG4781 / 37943
• FlyBaseID: FBgn0035043
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_001102659.1
• Gene: Lingo4 / 499668
• RGDID: 1562025
• Length: 618
• Species: Rattus norvegicus
• Alignment Length: 510
• Identity: 125/510 - (24%)
• Similarity: 177/510 - (34%)
• Gaps: 185/510 - (36%)

  Fly    98 LDSVPIFTSDSLHQLNLRHNNISQLVSGNFKQLTSLRELYLGWNSIGKLESGSFDGLPHLQVLDL 162
            ||:||.........|:|..|.:..|..|...:|..|:||.|.:|.:..||.|:|.||..|..|.|
  Rat    76 LDTVPGGLPLDTEVLDLSGNRLWGLQRGMLSRLGQLQELDLSYNQLSTLEPGAFHGLQSLLTLRL 140

  Fly   163 AHNNLHLLPGHLFAPLLVLGTLDISWNR-------RFNESG-------GD---------LYTGLG 204
            ..|.|.::...:|:.|..|..||:..|:       .|.|.|       ||         .::||.
  Rat   141 QGNRLRIVGPGIFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQQLEVGDNHLVFVAPGAFSGLA 205

  Fly   205 VNWKLSTLRLDACSLNDL------HLP--VNAPLKELSLRRNQLKRIPTQLPETLLRLDISDNLL 261
               ||||:.|:.|:|:.:      .||  |...|:||.:.|         ||...||
  Rat   206 ---KLSTITLERCNLSTVPGLALAQLPALVALRLRELDIER---------LPSGALR-------- 250

  Fly   262 EELLPEDTANLTQVRQLFIEDMPVLQRVVANSL----------THVDVLETLSFQNSRQLSHLDA 316
                     .|.|:::|.|...|.|:.:...||          ||.: |.::.||....||.|..
  Rat   251 ---------GLGQLKELEIHHWPSLEALDPGSLVGLNLSSLAITHCN-LSSVPFQALHHLSFLQV 305

  Fly   317 --EAFGPIMTTPTKK-----------------RALRSLSFRG-----------TMLRTFNSTLAP 351
              .:..||...|.::                 .::.:.:|.|           ..|:|...|..|
  Rat   306 LDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFP 370

  Fly   352 IFTQLAELDLNGLPLQCDCELVWLKQL---------------PVQTNGR---------------C 386
            ...:|..|.|:|.||.|||.|:||.:|               |....|:               |
  Rat   371 SPDKLVTLRLSGNPLTCDCRLLWLLRLRRRLDFGTSPPACAGPQHVQGKNLREFSDILPPGHFTC 435

  Fly   387 YKPARIR------------GMLVTSARGDAFSCDT--WPR----W-------------------- 413
             |||.||            |..|.|..||.....|  |.|    |
  Rat   436 -KPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPQGSWLGRVGRVRVLEDGTLEIRSV 499

  Fly   414 ------AYGLVVLSLIALSAAGIYLIVMGLRPHRG------VTMRRKVGAGSPYA 456
                  ||..||.::....:...:|.|:.:.|..|      |||   .|...|::
  Rat   500 QLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNVTM---PGIPGPFS 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4781	NP_611951.1	LRR	<90..367	CDD:443914	87/339 (26%)
		leucine-rich repeat	90..108	CDD:275380	4/9 (44%)
		leucine-rich repeat	109..132	CDD:275380	6/22 (27%)
		leucine-rich repeat	133..156	CDD:275380	11/22 (50%)
		leucine-rich repeat	157..180	CDD:275380	7/22 (32%)
		leucine-rich repeat	181..208	CDD:275380	11/49 (22%)
		leucine-rich repeat	230..253	CDD:275380	6/22 (27%)
		leucine-rich repeat	254..274	CDD:275380	1/19 (5%)
		leucine-rich repeat	275..299	CDD:275380	8/33 (24%)
		leucine-rich repeat	300..319	CDD:275380	6/20 (30%)
Lingo4	NP_001102659.1	leucine-rich repeat	87..110	CDD:275380	6/22 (27%)
		LRR	<88..441	CDD:443914	97/383 (25%)
		leucine-rich repeat	111..134	CDD:275380	11/22 (50%)
		leucine-rich repeat	135..158	CDD:275380	7/22 (32%)
		leucine-rich repeat	159..182	CDD:275380	6/22 (27%)
		leucine-rich repeat	183..206	CDD:275380	4/25 (16%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	10/48 (21%)
		leucine-rich repeat	255..302	CDD:275380	12/47 (26%)
		leucine-rich repeat	303..326	CDD:275380	4/22 (18%)
		leucine-rich repeat	327..348	CDD:275380	1/20 (5%)
		leucine-rich repeat	351..374	CDD:275380	4/22 (18%)
		IG_like	445..526	CDD:214653	14/80 (18%)
		Ig strand B	456..460	CDD:409353	1/3 (33%)
		Ig strand C	469..473	CDD:409353	1/3 (33%)
		Ig strand E	492..496	CDD:409353	0/3 (0%)
		Ig strand F	506..511	CDD:409353	2/4 (50%)
		Ig strand G	519..522	CDD:409353	0/2 (0%)