DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4781 and CG5810

DIOPT Version :9

Sequence 1:	NP_611951.1	Gene:	CG4781 / 37943	FlyBaseID:	FBgn0035043	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_650952.2	Gene:	CG5810 / 42513	FlyBaseID:	FBgn0038866	Length:	428	Species:	Drosophila melanogaster

Alignment Length:	343	Identity:	86/343 - (25%)
Similarity:	140/343 - (40%)	Gaps:	79/343 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLLTQLLAAHVARAEVIDAEETDRFCYPESSKNSRRSCECSNVSASPWGNRALRIDCSYKDYKVA 78
            |.|.||:..||...|:   ::.:..|: :.:||.:|         ..:|..|||:    .|....
  Fly    84 LNLPQLVEFHVLECEL---QQIESVCF-DGAKNLKR---------LNFGGNALRV----LDSNTF 131

  Fly    79 DLSLLLPLYIDSLDLSWNALDSVP--IFTS-DSLHQLNLRHNNISQLVSGNFKQLTSLRELYLGW 140
            :|:..|    :.|:||.|.|:.:|  ||.. .:|.::||.:|.:..|....|.||.||:.:.:..
  Fly   132 ELATQL----EELNLSDNQLEDLPTTIFRPLKNLQKINLSNNRLITLSQHIFSQLGSLKSINVDS 192

  Fly   141 NSIGKLESGSF-DGLPHLQVLDLAHNNLHLLPGHLFAPLLVLGTLDISWNRRFNESGGDLYTGLG 204
            |.:.:|....| |...||.......|.|..:|.::|..   :..|.:|:|.:...        |.
  Fly   193 NQLVELPGELFRDQRKHLSEFSAQSNQLVRIPFNIFRE---IDHLSLSFNPQLRR--------LH 246

  Fly   205 VNWKLSTLRLDACSLND---------LHLPVNAPLKELSLRRNQ----LKRIPTQL--------P 248
            ::.|::.|....|.|..         :.|..|..|.||.:.:.|    |....|.|        .
  Fly   247 LSAKINELEATNCDLESVELDGRVIGVQLEANPKLHELKISQPQDLEHLYLANTNLYRLDFLSKA 311

  Fly   249 ETLLRLDISD--NLLEELLPEDTANLTQVRQLFIEDMPVLQRVVANSLTHVDVLETLSFQNSRQL 311
            ..|:.||::|  ||.:  ||:.|:.....|..|..|     .:.:|   |:|:|..|...|..::
  Fly   312 SKLVDLDVTDIVNLAD--LPKITSAKGLERLSFTYD-----NLTSN---HMDMLPHLKDLNYLEI 366

  Fly   312 SH----------LDAEAF 319
            ||          ||.:.|
  Fly   367 SHEKGKEIFIKDLDEDFF 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4781	NP_611951.1	leucine-rich repeat	90..108	CDD:275380	8/20 (40%)
		LRR_8	108..167	CDD:290566	17/59 (29%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		LRR_RI	<121..>261	CDD:238064	38/163 (23%)
		leucine-rich repeat	133..156	CDD:275380	5/23 (22%)
		leucine-rich repeat	157..180	CDD:275380	5/22 (23%)
		leucine-rich repeat	181..208	CDD:275380	4/26 (15%)
		leucine-rich repeat	230..253	CDD:275380	8/34 (24%)
		leucine-rich repeat	254..274	CDD:275380	8/21 (38%)
		leucine-rich repeat	275..299	CDD:275380	5/23 (22%)
		leucine-rich repeat	300..319	CDD:275380	7/28 (25%)
CG5810	NP_650952.2	leucine-rich repeat	65..88	CDD:275380	2/3 (67%)
		LRR_8	87..147	CDD:290566	20/80 (25%)
		leucine-rich repeat	89..112	CDD:275380	5/26 (19%)
		leucine-rich repeat	113..136	CDD:275380	7/35 (20%)
		LRR_8	135..195	CDD:290566	20/63 (32%)
		LRR_4	135..175	CDD:289563	13/43 (30%)
		leucine-rich repeat	137..160	CDD:275380	9/26 (35%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		leucine-rich repeat	185..209	CDD:275380	5/23 (22%)
		leucine-rich repeat	210..231	CDD:275380	5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100