DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4781 and CG5819

DIOPT Version :9

Sequence 1:	NP_611951.1	Gene:	CG4781 / 37943	FlyBaseID:	FBgn0035043	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	133/570 - (23%)
Similarity:	209/570 - (36%)	Gaps:	190/570 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SCECSNVSASPWGNR------ALRIDCSYKDYKV-----------ADLS----LLLP-LY--IDS 90
            ||...|   .||..|      :|..|||.:..:.           .|||    |..| ||  |||
  Fly    17 SCRAVN---CPWPCRCTWVVDSLYADCSRRSLQTYPNFDGIPVEHLDLSGNKFLEFPTLYADIDS 78

  Fly    91 ---LDLSWNALDSVPI-----FTSDSLHQLNLRHNNIS--QLVSGN--FKQLTSLRELYLGWNSI 143
               ||||.|.:.|:..     ||  ||..|.|.:|:|.  :.:|.|  ||...||:.|.|..|.:
  Fly    79 LIYLDLSSNYISSIGAKTLIGFT--SLRTLLLANNSIDSWESLSPNEAFKYAPSLKRLGLDGNRL 141

  Fly   144 GKLESG-SFD---------------------------GLPHLQVLDLAHNNLHLLPGHLFAPLLV 180
            |...:| ||:                           .||:|:.|:||:|.|..:..   .|...
  Fly   142 GSFGNGESFELLTSSSLTDLGLSSCGISSIGGDQMVNQLPNLERLNLANNQLAQIAA---LPSRT 203

  Fly   181 LGTLDISWNRRFNESGGDL------------------YTGLG----VNWKLSTLRLDACSLNDLH 223
            |..||:|.....|.||..|                  :..|.    :.:.|..|.:..|:|:.:.
  Fly   204 LRVLDLSNCSIKNLSGFFLDAMQNLEALNLSRNTELQFDSLSEDPILTYMLRKLDVSYCNLDSIE 268

  Fly   224 LPVNAPLKELSLRRNQLK--RIPTQLPETLLR-LDISDNLLEELLPEDTANLTQVRQL------- 278
            |.....|.|:.|:.|.|:  .:.|....::|. :|:|.|:|..:..:..|.|.::::|
  Fly   269 LSGLPQLTEVRLQGNLLRVVDVNTFANNSMLEVVDLSQNVLRHIGQDAFAKLKRLKELNLAFNEI 333

  Fly   279 ------FIEDMPV-------------LQRVVANSLTHVDV-------LETLSFQNSRQLSHLDAE 317
                  ||.:..|             |.::|:||:..:::       :|:.:..:...:..||.
  Fly   334 ARLDRNFIRNNDVLVELNLSRNVLQKLTKIVSNSVRTINMSWCEITSIESTALSSLSVIQKLDL- 397

  Fly   318 AFGPIMTTPT--KKRALRSLSFRGTMLRTFNSTLAPIFTQLAELDLNG----------------- 363
            :...|...||  :...|:.|:.....|.|..:.....|.:||:|.|||
  Fly   398 SNNLITDMPTFMRSETLQQLNLANCRLTTVRNNTFREFPELADLHLNGNRLTSPIPPNYFDGNKF 462

  Fly   364 --------LPLQCDC---------ELVWLKQLPVQTNG--RCYKPARIRGMLVTSARGDAFSC-D 408
                    .|..|||         :.:..|...::...  ||..||...|.|.      .|:| |
  Fly   463 LDQLWLGDNPWICDCHSPLFVDFYDYLTAKPAKIKDRNHLRCAAPAVFYGKLW------EFACAD 521

  Fly   409 TW---------PRWAYGLVVLSLIALSAAGIYLIVMGLRPHRGVTMRRKV 449
            .|         ...|:.:::|:|:.|.|     :|:|....:....:|||
  Fly   522 VWILNARTSSTGEKAWSIIMLTLLGLGA-----LVLGYACLQKYLRKRKV 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4781	NP_611951.1	leucine-rich repeat	90..108	CDD:275380	9/25 (36%)
		LRR_8	108..167	CDD:290566	26/90 (29%)
		leucine-rich repeat	109..132	CDD:275380	9/26 (35%)
		LRR_RI	<121..>261	CDD:238064	46/194 (24%)
		leucine-rich repeat	133..156	CDD:275380	9/50 (18%)
		leucine-rich repeat	157..180	CDD:275380	7/22 (32%)
		leucine-rich repeat	181..208	CDD:275380	9/48 (19%)
		leucine-rich repeat	230..253	CDD:275380	6/24 (25%)
		leucine-rich repeat	254..274	CDD:275380	6/19 (32%)
		leucine-rich repeat	275..299	CDD:275380	8/49 (16%)
		leucine-rich repeat	300..319	CDD:275380	3/18 (17%)
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	8/21 (38%)
		LRR_RI	<58..236	CDD:238064	54/182 (30%)
		LRR_8	78..141	CDD:290566	24/64 (38%)
		leucine-rich repeat	79..102	CDD:275380	8/24 (33%)
		leucine-rich repeat	103..130	CDD:275380	9/26 (35%)
		leucine-rich repeat	131..155	CDD:275380	8/23 (35%)
		LRR_8	156..214	CDD:290566	13/60 (22%)
		leucine-rich repeat	158..182	CDD:275380	1/23 (4%)
		LRR_8	202..285	CDD:290566	18/82 (22%)
		leucine-rich repeat	204..227	CDD:275380	8/22 (36%)
		leucine-rich repeat	254..274	CDD:275380	5/19 (26%)
		LRR_8	273..333	CDD:290566	14/59 (24%)
		leucine-rich repeat	275..298	CDD:275380	6/22 (27%)
		LRR_RI	277..>471	CDD:238064	37/194 (19%)
		leucine-rich repeat	299..322	CDD:275380	7/22 (32%)
		LRR_8	321..402	CDD:290566	11/81 (14%)
		leucine-rich repeat	323..346	CDD:275380	3/22 (14%)
		leucine-rich repeat	347..391	CDD:275380	5/43 (12%)
		leucine-rich repeat	392..413	CDD:275380	5/21 (24%)
		LRR_8	393..448	CDD:290566	16/55 (29%)
		leucine-rich repeat	414..437	CDD:275380	5/22 (23%)
		LRRCT	471..517	CDD:214507	11/51 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438708
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940