Protein Alignment CG4781 and TSKU

DIOPT Version :9

• Sequence 1: NP_611951.1
• Gene: CG4781 / 37943
• FlyBaseID: FBgn0035043
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_001305406.1
• Gene: TSKU / 25987
• HGNCID: 28850
• Length: 367
• Species: Homo sapiens
• Alignment Length: 425
• Identity: 94/425 - (22%)
• Similarity: 149/425 - (35%)
• Gaps: 147/425 - (34%)

  Fly    10 LTFALLLTQLLAAHVARAEVIDAEETDRFCYPESSKNSRRSCECSNVSASPWGNRAL-RIDCSYK 73
            :.:.|||  |||        :...:|.|.|:|        .|:|...:...:.:.:| |:|||..
Human    15 MPWPLLL--LLA--------VSGAQTTRPCFP--------GCQCEVETFGLFDSFSLTRVDCSGL 61

  Fly    74 DYKVADLSLLLPLYIDSLDLSWNALDSV-------PIFTSDSLHQLNLRHNNISQLVSGNFKQLT 131
            ...:  :.:.:||....||||.|.|:.|       |.:|  :|..|:|.||.::.:....|.:|.
Human    62 GPHI--MPVPIPLDTAHLDLSSNRLEMVNESVLAGPGYT--TLAGLDLSHNLLTSISPTAFSRLR 122

  Fly   132 SLRELYLGWNSIGKLESGSFDGLP-------HLQV------------------LDLAHNNLHLLP 171
            .|..|.|..|.:..|.:.||...|       |.|:                  :||:||.:|.|.
Human   123 YLESLDLSHNGLTALPAESFTSSPLSDVNLSHNQLREVSVSAFTTHSQGRALHVDLSHNLIHRLV 187

  Fly   172 GH-----LFAPLLVLGTLDISWNRRFNESGGDLYTGLGVNWKLSTLRLDACSLNDLHLPVNAPLK 231
            .|     |.||  .:.:|:::|||                               ||...|  |:
Human   188 PHPTRAGLPAP--TIQSLNLAWNR-------------------------------LHAVPN--LR 217

  Fly   232 ELSLRRNQLKRIPTQLPETLLRLDISDNLLEELLPEDTANLTQVRQLFIEDMPVLQRVVANSLTH 296
            :|.||                .|.:..|.|..:.|...|.|..:..|.:..:..|..:..:....
Human   218 DLPLR----------------YLSLDGNPLAVIGPGAFAGLGGLTHLSLASLQRLPELAPSGFRE 266

  Fly   297 VDVLETLSFQNSRQLSHLDAEAFGPIMTTPTKKRALRSLSFRGTMLRTFNSTLAPIFTQLAELDL 361
            :..|:.|....:.:|:...||.|..:                               :.|.||||
Human   267 LPGLQVLDLSGNPKLNWAGAEVFSGL-------------------------------SSLQELDL 300

  Fly   362 NG-----LPLQCDCELVWLKQLPVQTNGRCYKPAR 391
            :|     ||......|..|:.:.|..:.||.:..|
Human   301 SGTNLVPLPEALLLHLPALQSVSVGQDVRCRRLVR 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4781	NP_611951.1	leucine-rich repeat	90..108	CDD:275380	9/24 (38%)
		LRR_8	108..167	CDD:290566	21/83 (25%)
		leucine-rich repeat	109..132	CDD:275380	7/22 (32%)
		LRR_RI	<121..>261	CDD:238064	35/169 (21%)
		leucine-rich repeat	133..156	CDD:275380	8/29 (28%)
		leucine-rich repeat	157..180	CDD:275380	11/45 (24%)
		leucine-rich repeat	181..208	CDD:275380	4/26 (15%)
		leucine-rich repeat	230..253	CDD:275380	4/22 (18%)
		leucine-rich repeat	254..274	CDD:275380	6/19 (32%)
		leucine-rich repeat	275..299	CDD:275380	2/23 (9%)
		leucine-rich repeat	300..319	CDD:275380	5/18 (28%)
TSKU	NP_001305406.1	LRR_RI	52..305	CDD:238064	74/338 (22%)
		leucine-rich repeat	76..99	CDD:275380	9/24 (38%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		LRR_8	103..157	CDD:290566	15/53 (28%)
		leucine-rich repeat	124..145	CDD:275380	7/20 (35%)
		leucine-rich repeat	147..170	CDD:275380	2/22 (9%)
		leucine-rich repeat	171..197	CDD:275380	8/25 (32%)
		leucine-rich repeat	200..219	CDD:275380	8/51 (16%)
		LRR_8	221..279	CDD:290566	12/73 (16%)
		leucine-rich repeat	221..244	CDD:275380	8/38 (21%)
		leucine-rich repeat	245..269	CDD:275380	2/23 (9%)
		LRR_8	268..321	CDD:290566	16/83 (19%)
		leucine-rich repeat	270..294	CDD:275380	6/54 (11%)
		leucine-rich repeat	295..316	CDD:275380	8/20 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100