DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4781 and lron-5

DIOPT Version :9

Sequence 1:	NP_611951.1	Gene:	CG4781 / 37943	FlyBaseID:	FBgn0035043	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_497943.2	Gene:	lron-5 / 184307	WormBaseID:	WBGene00008656	Length:	656	Species:	Caenorhabditis elegans

Alignment Length:	371	Identity:	85/371 - (22%)
Similarity:	122/371 - (32%)	Gaps:	113/371 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 VSASPWGNRALRIDCSYKDYKVADLSLLLPLYIDSLDLSWNALDSVPIFTSDSLHQLNLRHNNIS 120
            |....|..|..|:    |...::...  |||:.|    :|.|       ....||.|::......
Worm   250 VGFEEWLERKSRV----KSLNISHCQ--LPLHED----TWTA-------CGQFLHSLDISGIGAK 297

  Fly   121 QLVSGNFKQLTSLRELYLGWNSIGK------------LESGSFDGLP---------HLQVLDLAH 164
            :|   .|.:...:|.::...|.|..            ||...|...|         .|..|.|:|
Worm   298 RL---RFSRFCPIRSVFARDNLISSVYIDAVSMESLHLERNMFSEFPIPPPGVELTELHTLGLSH 359

  Fly   165 NNLHLLPGHLFAPLLVLGTLDISWNRRFNESGGDLYTGLGVNWKLSTLRLDACSLNDLHLPVNAP 229
            |.:..||.|.......|...|:|.| :.:|.....:..:|:.
Worm   360 NLMTSLPPHALQSYPNLQHFDVSSN-QLSEIDPQAFPSIGLG----------------------- 400

  Fly   230 LKELSLRRNQLKRIPTQLPETLLRLDISDNLLEELLPEDTANLTQVRQLFIEDMPVLQRVVANS- 293
            |..|.|..|||..:|..:..:||.||:|.|.:..|.|.....|..::||.|...|.|.....|.
Worm   401 LISLDLSSNQLSSLPHPILPSLLLLDLSFNTISHLDPHFFTGLPMLQQLRIASNPTLFSRCPNRD 465

  Fly   294 ----LTHVDVLETL--------SFQNSRQLSHLDAEAFGPIMTTPTKKRALRSLSFRGTMLRTFN 346
                ..|:|.|.:|        ..:.|....||               |.|:||..||..:|..:
Worm   466 SPCWSDHLDELTSLVDLDISNSGLEFSLHWRHL---------------RTLKSLILRGNEIRIID 515

  Fly   347 STLAP-------------IFT-------QLAELDLNGLPLQCDCEL 372
            |...|             .||       .|.:|.::..||:|||.|
Worm   516 SKSLPENLRTLDLGENRVQFTSNFSKLEHLRDLRVDQNPLRCDCSL 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4781	NP_611951.1	leucine-rich repeat	90..108	CDD:275380	2/17 (12%)
		LRR_8	108..167	CDD:290566	17/79 (22%)
		leucine-rich repeat	109..132	CDD:275380	5/22 (23%)
		LRR_RI	<121..>261	CDD:238064	36/160 (23%)
		leucine-rich repeat	133..156	CDD:275380	7/43 (16%)
		leucine-rich repeat	157..180	CDD:275380	8/22 (36%)
		leucine-rich repeat	181..208	CDD:275380	6/26 (23%)
		leucine-rich repeat	230..253	CDD:275380	8/22 (36%)
		leucine-rich repeat	254..274	CDD:275380	7/19 (37%)
		leucine-rich repeat	275..299	CDD:275380	7/28 (25%)
		leucine-rich repeat	300..319	CDD:275380	5/26 (19%)
lron-5	NP_497943.2	leucine-rich repeat	51..72	CDD:275380
		LRR_8	72..131	CDD:338972
		leucine-rich repeat	73..96	CDD:275380
		LRR	<92..>272	CDD:227223	5/27 (19%)
		leucine-rich repeat	97..120	CDD:275380
		leucine-rich repeat	121..146	CDD:275380
		leucine-rich repeat	147..168	CDD:275380
		leucine-rich repeat	169..208	CDD:275380
		leucine-rich repeat	209..237	CDD:275380
		leucine-rich repeat	238..284	CDD:275380	11/50 (22%)
		leucine-rich repeat	327..351	CDD:275380	4/23 (17%)
		internalin_A	345..>576	CDD:380193	62/256 (24%)
		leucine-rich repeat	352..375	CDD:275380	8/22 (36%)
		leucine-rich repeat	376..391	CDD:275380	5/15 (33%)
		leucine-rich repeat	401..445	CDD:275380	16/43 (37%)
		leucine-rich repeat	446..478	CDD:275380	9/31 (29%)
		leucine-rich repeat	479..500	CDD:275380	4/35 (11%)
		leucine-rich repeat	501..522	CDD:275380	8/20 (40%)
		leucine-rich repeat	523..544	CDD:275380	2/20 (10%)
		LRRCT	553..601	CDD:214507	6/9 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100