DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4781 and sym-1

DIOPT Version :9

Sequence 1:	NP_611951.1	Gene:	CG4781 / 37943	FlyBaseID:	FBgn0035043	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_510426.1	Gene:	sym-1 / 181555	WormBaseID:	WBGene00006366	Length:	680	Species:	Caenorhabditis elegans

Alignment Length:	373	Identity:	89/373 - (23%)
Similarity:	147/373 - (39%)	Gaps:	85/373 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SCECS---NVSASPWGNRALRID----CSYKDYKVADLSLLLPLYIDSLDLSWNALDSVP---IF 104
            |.:|:   |::...:.|....||    |:......||....:.:.:.:|.|..|.:...|   :.
Worm   138 SLKCNKIENITTKAFVNMTSLIDVNLGCNQICSMAADTFANVKMSLQNLILDNNCMTEFPSKAVR 202

  Fly   105 TSDSLHQLNLRHNNISQLVSGNFKQLTSLRELYLGWNSIGKLESGSFDGLPHLQVLDLAHNNLHL 169
            ..::|..|::::|.|:.:...:|..||||..|.|..|:|.:::.|:....|:|..|.|..|||..
Worm   203 NMNNLIALHIKYNKINAIRQNDFVNLTSLSMLSLNGNNISEIKGGALQNTPNLHYLYLNENNLQT 267

  Fly   170 LPGHLFAPLLVLGTLDISWNRRFNESGGDLYTGLGVNWKLSTLRLDACSLNDLHLPVNAPLKELS 234
            |...:......|..||:|:| .|.:...:::.||                        ..::.|:
Worm   268 LDNGVLEQFKQLQVLDLSFN-NFTDITKEMFEGL------------------------ESIQHLN 307

  Fly   235 LRRNQLKRI-PTQLPET-LLRLDISDNLLEELLPEDTANLTQVRQLFIEDMPVLQRVVANSLTHV 297
            |..|::..: |.....| ||.|.:.:|.           ||:|.|..::..|.| |:|:.|..::
Worm   308 LDSNRISAVAPGAFAGTPLLLLWLPNNC-----------LTEVSQQTLKGAPFL-RMVSLSNNNI 360

  Fly   298 DVLETLSFQNSRQLSHLDAEAFGPIMTTPTKKRALRSLSFRGTMLRTFNSTLAP--IFTQLAELD 360
            ..:..|||.:...|..||. |...||:...|     |||             .|  :..:|.|..
Worm   361 REVHELSFDHLPNLHTLDL-ANNKIMSLQNK-----SLS-------------GPENLAVRLQENP 406

  Fly   361 L----NGLPLQCDCELVWLK---------QLPVQTNGRCYK--PARIR 393
            :    ||..:....|.:||.         :...||...|.|  |..||
Worm   407 VVCVKNGFHVLNSGEAIWLTNEANTICKGEWQAQTADLCPKAQPRPIR 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4781	NP_611951.1	leucine-rich repeat	90..108	CDD:275380	4/20 (20%)
		LRR_8	108..167	CDD:290566	19/58 (33%)
		leucine-rich repeat	109..132	CDD:275380	6/22 (27%)
		LRR_RI	<121..>261	CDD:238064	35/141 (25%)
		leucine-rich repeat	133..156	CDD:275380	6/22 (27%)
		leucine-rich repeat	157..180	CDD:275380	7/22 (32%)
		leucine-rich repeat	181..208	CDD:275380	8/26 (31%)
		leucine-rich repeat	230..253	CDD:275380	6/24 (25%)
		leucine-rich repeat	254..274	CDD:275380	3/19 (16%)
		leucine-rich repeat	275..299	CDD:275380	7/23 (30%)
		leucine-rich repeat	300..319	CDD:275380	6/18 (33%)
sym-1	NP_510426.1	leucine-rich repeat	62..81	CDD:275380
		LRR_5	74..208	CDD:290045	13/69 (19%)
		LRR_RI	81..384	CDD:238064	68/283 (24%)
		leucine-rich repeat	86..108	CDD:275380
		leucine-rich repeat	110..133	CDD:275380
		leucine-rich repeat	134..157	CDD:275380	4/18 (22%)
		leucine-rich repeat	158..182	CDD:275380	5/23 (22%)
		LRR_8	182..241	CDD:290566	16/58 (28%)
		leucine-rich repeat	183..206	CDD:275380	4/22 (18%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	19/84 (23%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	8/47 (17%)
		LRR_8	302..384	CDD:290566	25/94 (27%)
		leucine-rich repeat	303..323	CDD:275380	4/19 (21%)
		leucine-rich repeat	350..373	CDD:275380	7/23 (30%)
		leucine-rich repeat	374..394	CDD:275380	10/38 (26%)
		leucine-rich repeat	399..410	CDD:275378	2/10 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156340
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030