DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4781 and egg-6

DIOPT Version :9

Sequence 1:	NP_611951.1	Gene:	CG4781 / 37943	FlyBaseID:	FBgn0035043	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_492348.1	Gene:	egg-6 / 172670	WormBaseID:	WBGene00010621	Length:	961	Species:	Caenorhabditis elegans

Alignment Length:	377	Identity:	93/377 - (24%)
Similarity:	150/377 - (39%)	Gaps:	92/377 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LRID----CSY--KDYKVADLSLLLPLYIDSLDLSWNALDSVP---IFTSDSLHQLNLRHNNISQ 121
            ||::    |.:  |.......||:|      ||:|.|.||::|   :..:.:|..|:|..||||:
Worm   155 LRLENNAICDFPPKSLDAVKASLVL------LDVSGNCLDAIPAQILRNAANLMYLDLGSNNISE 213

  Fly   122 LVSGNFKQLTSLRELYLGWNSIGKLESGSFDGLPHLQVLDLAHNNLHLLPGHLFAPLLVLGTLDI 186
            :.:.....|..||||.:..|::.::...:|..:|.||.|.|..|.:..|.|:.......|..||:
Worm   214 INNFELMNLPFLRELRVQNNTLRRIHPMAFMNVPQLQYLYLQDNIISTLDGNRLQGFKNLEVLDV 278

  Fly   187 SWNRRFNESGGDLYTGLGVNWKLSTLRLDACSLNDLHLPVNAPLKELSLRRNQLKRIPTQLPETL 251
            |.|.        ||.              ..||.||     ..||::.:..|.:.:|.|
Worm   279 SNNA--------LYA--------------LPSLKDL-----PNLKQVRVDGNLITKIET------ 310

  Fly   252 LRLDISDNLLEELLPEDTANLTQVRQLFIE--DMPVLQRVVANSLTHVD--------VLETLSFQ 306
              |..|:|...:|:.....|:.|:.:...|  |..|:..|..|||..::        .|:.||.:
Worm   311 --LAFSNNPNLQLISVQNNNIVQISRNSFESLDKLVVLLVGNNSLAKIERGMFDGMKNLQQLSIR 373

  Fly   307 NSRQLSHLDAEAFGPIMTTPT-----------------KKRALRSLSFRGTMLRTFNSTLAPIF- 353
            |: .|:.|||.:|..:....|                 |...|..|......:..|.::   :|
Worm   374 NN-TLTALDASSFAQLAHLTTLDLGHNKIHDIEEGTFDKLSKLFWLDLSNNKISGFKTS---VFK 434

  Fly   354 TQLAELDLNGLPLQCDCE----LVWL------KQLPVQTNGRCYKPARIRGM 395
            .:::.:.|:|..|.||..    |.:|      ..||.|....|:.|.:..|:
Worm   435 KKISNILLDGNQLICDESFNEFLTYLIANKVRTFLPFQQEIMCHGPEKYAGV 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4781	NP_611951.1	leucine-rich repeat	90..108	CDD:275380	7/20 (35%)
		LRR_8	108..167	CDD:290566	20/58 (34%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		LRR_RI	<121..>261	CDD:238064	34/139 (24%)
		leucine-rich repeat	133..156	CDD:275380	6/22 (27%)
		leucine-rich repeat	157..180	CDD:275380	7/22 (32%)
		leucine-rich repeat	181..208	CDD:275380	7/26 (27%)
		leucine-rich repeat	230..253	CDD:275380	5/22 (23%)
		leucine-rich repeat	254..274	CDD:275380	5/19 (26%)
		leucine-rich repeat	275..299	CDD:275380	7/33 (21%)
		leucine-rich repeat	300..319	CDD:275380	8/18 (44%)
egg-6	NP_492348.1	LRR_8	107..162	CDD:290566	2/6 (33%)
		leucine-rich repeat	107..127	CDD:275380
		leucine-rich repeat	128..151	CDD:275380
		LRR_RI	<144..281	CDD:238064	40/131 (31%)
		leucine-rich repeat	152..200	CDD:275380	14/50 (28%)
		LRR_8	176..233	CDD:290566	22/62 (35%)
		leucine-rich repeat	201..224	CDD:275380	8/22 (36%)
		LRR_8	225..283	CDD:290566	19/65 (29%)
		leucine-rich repeat	225..248	CDD:275380	6/22 (27%)
		LRR_RI	<240..458	CDD:238064	58/256 (23%)
		leucine-rich repeat	249..272	CDD:275380	7/22 (32%)
		LRR_8	271..329	CDD:290566	20/92 (22%)
		leucine-rich repeat	273..294	CDD:275380	11/47 (23%)
		leucine-rich repeat	295..318	CDD:275380	8/30 (27%)
		LRR_8	317..375	CDD:290566	13/57 (23%)
		leucine-rich repeat	319..342	CDD:275380	4/22 (18%)
		leucine-rich repeat	343..366	CDD:275380	5/22 (23%)
		LRR_8	365..425	CDD:290566	13/60 (22%)
		leucine-rich repeat	367..390	CDD:275380	9/23 (39%)
		leucine-rich repeat	391..414	CDD:275380	2/22 (9%)
		leucine-rich repeat	415..434	CDD:275380	3/21 (14%)
		leucine-rich repeat	437..449	CDD:275378	3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100