DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4781 and Gp5

DIOPT Version :9

Sequence 1:	NP_611951.1	Gene:	CG4781 / 37943	FlyBaseID:	FBgn0035043	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_032174.2	Gene:	Gp5 / 14729	MGIID:	1096363	Length:	567	Species:	Mus musculus

Alignment Length:	558	Identity:	131/558 - (23%)
Similarity:	205/558 - (36%)	Gaps:	157/558 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLLTQLLAAHVA--RAEVIDAEETDRFCYPESSKNSRRSCECSNVSASPWGNRAL---------- 66
            :|.:.||:|.:|  ||:.....:|.: |.      .|.:.:||..|.:......|
Mouse     1 MLRSALLSAVLALLRAQPFPCPKTCK-CV------VRDAAQCSGGSVAHIAELGLPTNLTHILLF 58

  Fly    67 RID------CSYKDYKVADLSLLLPLYIDSLD--------------LSWNALDSVPIFTSDS--- 108
            |:|      .|:....|....:|...:|.::|              |:.|.:..:|....|.
Mouse    59 RMDQGILRNHSFSGMTVLQRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKISRLPRAILDKMVL 123

  Fly   109 LHQLNLRHNNISQLVSGNFKQLTSLRELYLGWNSIGKLESGSFDGLPHLQVLDLAHNNLHLLPGH 173
            |.||.|.||.:..|....|:||.:|:||.|..|.:..|.:..|..|..|::|||:.|||..||..
Mouse   124 LEQLFLDHNALRDLDQNLFQQLRNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNLTHLPKG 188

  Fly   174 LFAPLLVLGTLDISWNRRFNESGGDLYTGLGVNWKLSTLRLDACSLNDLHLPVNAP--------L 230
            |....:.|..|.:..|:..:...| |.:.||.   |:.|||:.     .||...||        |
Mouse   189 LLGAQVKLEKLLLYSNQLTSVDSG-LLSNLGA---LTELRLER-----NHLRSVAPGAFDRLGNL 244

  Fly   231 KELSLRRNQLKRIPTQL---PETLLRLDISDNLLEELLPEDTANLTQVRQLFIEDMPVLQRVVAN 292
            ..|:|..|.|:.:|..|   ..::.||.:.:|.||||.......:..:|:|::.... |..:.|.
Mouse   245 SSLTLSGNLLESLPPALFLHVSSVSRLTLFENPLEELPDVLFGEMAGLRELWLNGTH-LSTLPAA 308

  Fly   293 SLTHVDVLETLSFQNSRQLSHLDAEAFG-----PIMTTPTKKRA------------LRSLSFRGT 340
            :..::..|:||....:.:||.|....|.     .::...|...|            ||.:|.|..
Mouse   309 AFRNLSGLQTLGLTRNPRLSALPRGVFQGLRELRVLALHTNALAELRDDALRGLGHLRQVSLRHN 373

  Fly   341 MLRTFNSTL---------------------APIFT---QLAELDLNGLPLQCDCE----LVWLKQ 377
            .||....||                     ..:|.   ||.::.|...|..|||.    |.||:.
Mouse   374 RLRALPRTLFRNLSSLESVQLEHNQLETLPGDVFAALPQLTQVLLGHNPWLCDCGLWPFLQWLRH 438

  Fly   378 LPVQTNGRCYKPARIRGMLVTSA-------RGDAFSCD--------------------------- 408
            .| ...|| .:|.:.||....::       :||.:..|
Mouse   439 HP-DILGR-DEPPQCRGPEPRASLSFWELLQGDPWCPDPRSLPLDPPTENALEAPVPSWLPNSWQ 501

  Fly   409 --TWP-----------RWAYGLVVLSLIALSAAGIYLI 433
              ||.           |..:||.:|.|:|.:....:::
Mouse   502 SQTWAQLVARGESPNNRLYWGLYILLLVAQAIIAAFIV 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4781	NP_611951.1	leucine-rich repeat	90..108	CDD:275380	4/31 (13%)
		LRR_8	108..167	CDD:290566	23/61 (38%)
		leucine-rich repeat	109..132	CDD:275380	10/22 (45%)
		LRR_RI	<121..>261	CDD:238064	47/150 (31%)
		leucine-rich repeat	133..156	CDD:275380	8/22 (36%)
		leucine-rich repeat	157..180	CDD:275380	10/22 (45%)
		leucine-rich repeat	181..208	CDD:275380	7/26 (27%)
		leucine-rich repeat	230..253	CDD:275380	7/25 (28%)
		leucine-rich repeat	254..274	CDD:275380	6/19 (32%)
		leucine-rich repeat	275..299	CDD:275380	4/23 (17%)
		leucine-rich repeat	300..319	CDD:275380	6/18 (33%)
Gp5	NP_032174.2	LRR 1	75..96		4/20 (20%)
		LRR_8	76..134	CDD:290566	13/57 (23%)
		leucine-rich repeat	76..99	CDD:275380	3/22 (14%)
		LRR 2	99..120		3/20 (15%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		LRR 3	123..144		8/20 (40%)
		LRR_8	124..182	CDD:290566	23/57 (40%)
		leucine-rich repeat	124..147	CDD:275380	10/22 (45%)
		LRR_RI	126..402	CDD:238064	77/285 (27%)
		LRR 4	147..168		7/20 (35%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		LRR 5	171..193		10/21 (48%)
		leucine-rich repeat	172..195	CDD:275380	10/22 (45%)
		LRR_8	195..254	CDD:290566	19/67 (28%)
		LRR 6	195..216		5/21 (24%)
		leucine-rich repeat	196..219	CDD:275380	6/23 (26%)
		LRR 7	219..240		8/28 (29%)
		leucine-rich repeat	220..243	CDD:275380	8/27 (30%)
		LRR_8	243..302	CDD:290566	16/59 (27%)
		LRR 8	243..264		7/20 (35%)
		leucine-rich repeat	244..267	CDD:275380	7/22 (32%)
		LRR 9	267..288		7/20 (35%)
		leucine-rich repeat	268..291	CDD:275380	7/22 (32%)
		LRR 10	291..312		4/21 (19%)
		leucine-rich repeat	292..315	CDD:275380	4/23 (17%)
		LRR_8	314..375	CDD:290566	13/60 (22%)
		LRR 11	315..337		7/21 (33%)
		leucine-rich repeat	316..338	CDD:275380	7/21 (33%)
		LRR 12	340..361		2/20 (10%)
		leucine-rich repeat	341..364	CDD:275380	2/22 (9%)
		LRR_8	364..422	CDD:290566	12/57 (21%)
		LRR 13	364..385		8/20 (40%)
		leucine-rich repeat	365..388	CDD:275380	8/22 (36%)
		LRR 14	388..409		1/20 (5%)
		leucine-rich repeat	389..410	CDD:275380	1/20 (5%)
		TPKR_C2	421..>454	CDD:301599	12/34 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910