DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4781 and LOC100151059

DIOPT Version :9

Sequence 1:	NP_611951.1	Gene:	CG4781 / 37943	FlyBaseID:	FBgn0035043	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_017207970.1	Gene:	LOC100151059 / 100151059	-ID:	-	Length:	605	Species:	Danio rerio

Alignment Length:	439	Identity:	110/439 - (25%)
Similarity:	164/439 - (37%)	Gaps:	123/439 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 ASPWGNRALRIDCSYKDYKVADLSLLLPL----------------YIDSLDLSWNALDSVPIFTS 106
            ||.|....|.:           |.|||.|                .:.|:......|.:||....
Zfish     2 ASSWAVSRLCV-----------LGLLLALAAPSCSGCPPRCDCAAQLRSVSCQRRRLSAVPEGVP 55

  Fly   107 DSLHQLNLRHNNISQLVSGNFKQLTSLRELYLGWNSIGKLESGSFDGLPHLQVLDLAHNNLHLLP 171
            .....|:|..|.:..:.:|:......|.||.|..|.|..||..:|..|..|:.|.|..|.|.|:|
Zfish    56 TETRLLDLSRNRLRWVAAGDLAPYPRLEELDLSENLISTLEPNAFANLQALRTLRLRANQLKLVP 120

  Fly   172 GHLFAPLLVLGTLDISWNRRFNESGGDLYTGLGVNWKLSTLRLDACSLNDLHLPVN--------- 227
            ...||.|..|.|||:|.||          ..:.:::....||    ||.:|.:..|
Zfish   121 MGAFARLTNLTTLDLSENR----------IVILLDFTFQDLR----SLKNLEVGDNDLVYISHKA 171

  Fly   228 ----APLKELSLRRNQLKRIPTQLPETL-----LRL-DISDNLLEELLPEDTANLTQVRQLFIED 282
                ..|::|::.|..|..|..|....|     ||| .:|.:.|||   ::...||.:|.|.|.|
Zfish   172 FSGLLSLEDLTMARCNLTSISGQTLSYLRGLVTLRLRHLSISTLEE---QNFRKLTALRGLEIHD 233

  Fly   283 MPVLQRVVANSL------------THVDVLETLSFQNSRQLSHLDAEAFGPIMTTPT-------- 327
            .|.|:.:...|.            |::..:.:.||:|...|:.|:. ::.||.|..:
Zfish   234 WPFLEFISPLSFQGLNLSWLFITNTNITSVPSASFRNLAYLTALNL-SYNPISTLESWAFRDLIR 297

  Fly   328 -KK-------------------RALRSLSFRGTMLRTFNSTLAPIFTQLAELDLNGLPLQCDCEL 372
             |:                   |.:|.|:.....|.|...:.......|..|.::|.||.|||.|
Zfish   298 LKELHMVSTNLLTVEPHALGGLRQIRVLNLSNNDLVTLEESSFHSVNSLETLRVDGNPLSCDCRL 362

  Fly   373 VWLKQ----------LPVQTNGRCYKPARIRGMLVT----SARGDAFSC 407
            :|:.|          :||     |..|..::|.|::    ||..|.|:|
Zfish   363 LWILQRRRTLNFDGKMPV-----CAGPPEVQGYLLSMFTDSALFDYFTC 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4781	NP_611951.1	leucine-rich repeat	90..108	CDD:275380	4/17 (24%)
		LRR_8	108..167	CDD:290566	18/58 (31%)
		leucine-rich repeat	109..132	CDD:275380	4/22 (18%)
		LRR_RI	<121..>261	CDD:238064	45/158 (28%)
		leucine-rich repeat	133..156	CDD:275380	10/22 (45%)
		leucine-rich repeat	157..180	CDD:275380	10/22 (45%)
		leucine-rich repeat	181..208	CDD:275380	7/26 (27%)
		leucine-rich repeat	230..253	CDD:275380	7/27 (26%)
		leucine-rich repeat	254..274	CDD:275380	6/20 (30%)
		leucine-rich repeat	275..299	CDD:275380	8/35 (23%)
		leucine-rich repeat	300..319	CDD:275380	5/18 (28%)
LOC100151059	XP_017207970.1	LRRNT	26..60	CDD:214470	4/33 (12%)
		leucine-rich repeat	37..56	CDD:275380	4/18 (22%)
		leucine-rich repeat	58..81	CDD:275380	4/22 (18%)
		LRR_RI	61..332	CDD:238064	73/288 (25%)
		LRR_8	80..140	CDD:290566	27/69 (39%)
		leucine-rich repeat	82..105	CDD:275380	10/22 (45%)
		leucine-rich repeat	106..129	CDD:275380	10/22 (45%)
		LRR_8	128..188	CDD:290566	16/73 (22%)
		leucine-rich repeat	130..153	CDD:275380	9/36 (25%)
		leucine-rich repeat	154..177	CDD:275380	3/22 (14%)
		leucine-rich repeat	178..201	CDD:275380	7/22 (32%)
		leucine-rich repeat	202..225	CDD:275380	8/25 (32%)
		leucine-rich repeat	226..249	CDD:275380	7/22 (32%)
		LRR_8	249..308	CDD:290566	10/59 (17%)
		leucine-rich repeat	250..273	CDD:275380	4/22 (18%)
		leucine-rich repeat	274..295	CDD:275380	5/21 (24%)
		LRR_8	297..356	CDD:290566	9/58 (16%)
		leucine-rich repeat	298..321	CDD:275380	1/22 (5%)
		leucine-rich repeat	322..342	CDD:275380	4/19 (21%)
		leucine-rich repeat	346..358	CDD:275378	5/11 (45%)
		TPKR_C2	354..394	CDD:301599	14/44 (32%)
		I-set	409..499	CDD:254352
		Ig	424..492	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910