DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4781 and lrrc4b

DIOPT Version :9

Sequence 1:	NP_611951.1	Gene:	CG4781 / 37943	FlyBaseID:	FBgn0035043	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001096358.1	Gene:	lrrc4b / 100124949	XenbaseID:	XB-GENE-5945982	Length:	641	Species:	Xenopus tropicalis

Alignment Length:	376	Identity:	99/376 - (26%)
Similarity:	145/376 - (38%)	Gaps:	92/376 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SCECSNVSASPWGNRALRIDCSYKDYKVADLSLLLPLYIDSLDLSWNALDSVPIFTSDSLHQLNL 114
            :|.||        |:|.|:.|:.::                       |..||...|.:...|||
Frog    45 ACTCS--------NQASRVACTRRE-----------------------LMEVPESISVNTRYLNL 78

  Fly   115 RHNNISQLVSGNFKQLTSLRELYLGWNSIGKLESGSFDGLPHLQVLDLAHNNLHLLPGHLFAPLL 179
            :.|.|..:.:..||.|..|..|.|..|.|.|:|.|:|:|||:|..|:|..|.|..:|...|..|.
Frog    79 QENIIQVIKTDTFKHLRHLEILQLSKNLIRKIEVGAFNGLPNLSTLELFDNRLTTVPTQAFEYLS 143

  Fly   180 VLGTLDISWNRRFNESGGDLYTGLGVNWKLSTLRLDACSLNDLHLPVNAP------LKELSLRRN 238
            .|..|   |.|   .:..:.......|...|..|||...|..|.....|.      |:.|:|...
Frog   144 KLREL---WLR---NNPIESIPSYAFNRVPSLRRLDLGELKKLEYISEAAFEGLVNLRYLNLGMC 202

  Fly   239 QLKRIP--TQLPETLLRLDISDNLLEELLPEDTANLTQVRQLFIEDMPVLQRVVANSLTHVDVLE 301
            .||.||  |.|.. |..|::|.|.||.:.|.....||.:|:|::..            .||.::|
Frog   203 NLKDIPNLTALVR-LEELELSGNRLEMIRPGSFQGLTSLRKLWLMH------------AHVTIIE 254

  Fly   302 TLSFQNSRQLSHLDAEAFGPIMTTPTKKRALRSLSFRGTMLRTFNSTLAPIFTQLAELD---LNG 363
            ..:|.:.:.|..|                   :||....|     |....:||.|..|:   ||.
Frog   255 RNAFDDLKSLEEL-------------------NLSHNNLM-----SLPHDLFTPLHRLERVHLNH 295

  Fly   364 LPLQCDCELVWL-----KQLPVQTN--GRCYKPARIRGMLVTSARGDAFSC 407
            .|..|:|:::||     :.:|..|.  .||:.|..::...:.......|:|
Frog   296 NPWHCNCDVLWLSWWLKETVPNNTTCCARCHSPPNLKMRYIGELDQSHFTC 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4781	NP_611951.1	leucine-rich repeat	90..108	CDD:275380	4/17 (24%)
		LRR_8	108..167	CDD:290566	24/58 (41%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		LRR_RI	<121..>261	CDD:238064	48/147 (33%)
		leucine-rich repeat	133..156	CDD:275380	11/22 (50%)
		leucine-rich repeat	157..180	CDD:275380	8/22 (36%)
		leucine-rich repeat	181..208	CDD:275380	5/26 (19%)
		leucine-rich repeat	230..253	CDD:275380	10/24 (42%)
		leucine-rich repeat	254..274	CDD:275380	7/19 (37%)
		leucine-rich repeat	275..299	CDD:275380	4/23 (17%)
		leucine-rich repeat	300..319	CDD:275380	4/18 (22%)
lrrc4b	NP_001096358.1	LRRNT	42..75	CDD:214470	11/60 (18%)
		leucine-rich repeat	73..96	CDD:275380	8/22 (36%)
		leucine-rich repeat	97..120	CDD:275380	11/22 (50%)
		PPP1R42	100..297	CDD:411060	67/239 (28%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		leucine-rich repeat	145..168	CDD:275380	5/28 (18%)
		leucine-rich repeat	169..193	CDD:275380	6/23 (26%)
		leucine-rich repeat	194..215	CDD:275380	9/20 (45%)
		leucine-rich repeat	216..239	CDD:275380	8/22 (36%)
		leucine-rich repeat	240..263	CDD:275380	6/34 (18%)
		leucine-rich repeat	264..285	CDD:275380	8/44 (18%)
		LRRCT	296..346	CDD:214507	11/49 (22%)
		I-set	349..438	CDD:400151
		Ig strand A	349..352	CDD:409353
		Ig strand A'	356..359	CDD:409353
		Ig strand B	365..372	CDD:409353
		Ig strand C	378..383	CDD:409353
		Ig strand C'	386..388	CDD:409353
		Ig strand D	397..401	CDD:409353
		Ig strand E	404..408	CDD:409353
		Ig strand F	418..425	CDD:409353
		Ig strand G	428..438	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910