DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3640 and CRISPLD2

DIOPT Version :9

Sequence 1:	NP_611950.1	Gene:	CG3640 / 37942	FlyBaseID:	FBgn0035042	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	NP_113664.1	Gene:	CRISPLD2 / 83716	HGNCID:	25248	Length:	497	Species:	Homo sapiens

Alignment Length:	239	Identity:	52/239 - (21%)
Similarity:	92/239 - (38%)	Gaps:	66/239 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 REARLIPLSNQLQAFIVHQVNFYRNQVASGGLSAFGPARRMASVRWDPELAQLAELAAKRCSLSG 117
            |..|.||..::.:..::|  |..|.||..       .|..|..:.||.||.:.|...|.:|.
Human    46 RVRRAIPREDKEEILMLH--NKLRGQVQP-------QASNMEYMTWDDELEKSAAAWASQCI--- 98

  Fly   118 DGCRNTRRFKHVGQLTGHVIFSAGKHSDLELLRHK-----ISNWFGQYMRASKDLQAADPSS--- 174
                    ::| |..:  ::.|.|::......|::     :.:|:.:.    ||.....||.
Human    99 --------WEH-GPTS--LLVSIGQNLGAHWGRYRSPGFHVQSWYDEV----KDYTYPYPSECNP 148

  Fly   175 ---------NISSFRQLIQESSTHMGCGVLRQRSHMLW-----HQQFIVCNFA-RRNMPREQVYQ 224
                     ..:.:.|::..::..:||.|...|...:|     :..:.|||:: :.|...|..|:
Human   149 WCPERCSGPMCTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYK 213

  Fly   225 VGVAATGC-----RSGRNPRYPNLCALQEEY-------DVNAVD 256
            .|...:.|     .|.||    |||..:|.|       ::|.|:
Human   214 NGRPCSECPPSYGGSCRN----NLCYREETYTPKPETDEMNEVE 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3640	NP_611950.1	SCP_euk	65..213	CDD:240180	33/169 (20%)
CRISPLD2	NP_113664.1	SCP_euk	56..201	CDD:240180	33/171 (19%)
		LCCL	286..370	CDD:128866
		LCCL	387..479	CDD:128866
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151222
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1528782at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750