DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and tbxas1

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_991172.2	Gene:	tbxas1 / 792041	ZFINID:	ZDB-GENE-030131-8805	Length:	546	Species:	Danio rerio

Alignment Length:	560	Identity:	169/560 - (30%)
Similarity:	288/560 - (51%)	Gaps:	82/560 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VELSIFVAFIGL-LLYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKHSIDLHLRL 67
            :.|::.:..:.| |||.:|:..|....:.|:.|.||:|.:||:    :|.:..:.|...|  |..
Zfish    18 LSLTVCLFLLSLSLLYWYSISPFSNLERCGIKHPKPLPFIGNL----MMFRNGFFKSQAD--LIN 76

  Fly    68 KQHKVYGVFNLRDPLYYLSDPELIRQVGIKNFDTFTNH--RKGITEGFNDTSVISKSLLSLRDRR 130
            |..::.|.:..|.....::||:::|||.:|.|:.|.|.  .:|||:..:|      ||:.|:..:
Zfish    77 KYGRICGYYIGRRSTVIIADPDMLRQVMVKEFNKFPNRMTARGITKPMSD------SLIMLKGEQ 135

  Fly   131 WKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDA---GTSELELKDFFTRYTNDVIAT 192
            ||::||.|||||::.|:::|..||:    .|.:.:.|.|.:   ..:...:...|..:|.||||:
Zfish   136 WKRVRSILTPTFSAAKMKEMVPLIN----TATETLLRNLKSHAESENSFNIHKCFGCFTMDVIAS 196

  Fly   193 AAFGIQVNSFKDPNNEFFSIGQRISEFTFWGGLKVMLYILMPKLMKALR--VPVM---DMNNVDY 252
            .|||.||:|..:|::.|.....:...|:|:..: ::.::..|.|::.|.  :|..   :||:  :
Zfish   197 VAFGTQVDSQNNPDDPFVHQASKFFAFSFFRPI-MIFFMAFPFLLRLLAGLLPNKSRDEMNS--F 258

  Fly   253 FKKLVFGAMKYRKEQSIV--RPDMIHLLMEAQRQFK------------AEQE---GSAESAA--- 297
            |.:.:...:|.|.:.|..  |.|.:.|:::.:...|            |::|   |...|.|
Zfish   259 FTQCIQKMIKQRDDLSPEQRRKDFLQLMLDVRTNKKFLSVEHFDVVNDADEEAYDGHENSPANES 323

  Fly   298 ---QQDKAEFNDDDLLAQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGE- 358
               .|.|....:|:::.|..:|..||:||.:..|:||.|.|.::||.|:||       :|::.|
Zfish   324 TKRSQQKRMMTEDEIVGQSFIFLVAGYETSSNTLAFTCYLLAVHPECQKKL-------QEEVDEF 381

  Fly   359 ----KPLDYDTLMGMKYLNCVVSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVN---LREDDLV 416
                :.:||..:..:|||:.|:.||||.:||||.|.|         |.|.:.|:|   |.:...:
Zfish   382 FSRHETVDYANVQELKYLDMVICESLRLYPPAFRVAR---------DVEEDTVLNGQFLPKGASL 437

  Fly   417 HINVGALHHDPDNFPEPEQFRPERFDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQL 481
            .|..|.||:||:::.||.:|.||||..|.|.....|.|||||.|.|||:|.|||.:|:|..:..:
Zfish   438 EIPTGFLHYDPEHWTEPTKFIPERFTPEAKARRHPFVYLPFGAGPRSCVGMRLAQLEIKVALVHI 502

  Fly   482 VLRYHLKPTDRT--PADMMSSISGFRLLPRELFWCKLESR 519
            ..|:::...:.|  |.::.|..:   |.|:.....|:..|
Zfish   503 FRRFNVLACEDTEIPLELKSHTT---LGPKNGVMVKITER 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	158/519 (30%)
tbxas1	NP_991172.2	p450	51..536	CDD:278495	158/522 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750