Protein Alignment Cyp9c1 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_523850.1
• Gene: Cyp9c1 / 37941
• FlyBaseID: FBgn0015040
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 176/611 - (28%)
• Similarity: 284/611 - (46%)
• Gaps: 138/611 - (22%)

  Fly     1 MVFVELSIFVAFIGLLLYKW-SVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKHSIDLH 64
            ||.|.||  ||.:.||  || |...|....|.|:.|.||.|.:||:.:.    ::.:.:..::|
Human    15 MVTVALS--VALLALL--KWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF----RQGFWESQMEL- 70

  Fly    65 LRLKQHKVYGVFNLRDPL--YYL--------SDPELIRQVGIKNFDTFTNHRKGITEGFNDTSVI 119
                 .|:||      ||  |||        |:|::|:||.::||..|||.   :..|....||
Human    71 -----RKLYG------PLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNR---MASGLEFKSV- 120

  Fly   120 SKSLLSLRDRRWKQMRSTLTPTFTSLKIRQM---------------------------------- 150
            :.|:|.|||:||:::|..|...|:..|:.::
Human   121 ADSVLFLRDKRWEEVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIY 185

  Fly   151 ----FELIHFCNV----EAVDF----VQRQLDAGTSELELKDFFTRYTNDVIATAAFGIQVNSFK 203
                :..:.||.|    :|.|.    ::|..::|.: .:::..:..||.||:|:.|||..|:|::
Human   186 VNLHYATLPFCMVPLISQACDLLLAHLKRYAESGDA-FDIQRCYCNYTTDVVASVAFGTPVDSWQ 249

  Fly   204 DPNNEFFSIGQRISEFTFWGGLKVMLYILMPKLMKALRVPVMDMNNVD----YFKKLVFGAMKYR 264
            .|.:.|....:|..||.....:.|:| :..|.:|..| ..::...|.|    :|.||:...:..|
Human   250 APEDPFVKHCKRFFEFCIPRPILVLL-LSFPSIMVPL-ARILPNKNRDELNGFFNKLIRNVIALR 312

  Fly   265 KEQSIV--RPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFND--------------------- 306
            .:|:..  |.|.:.::::|:.        ||.....||.....|
Human   313 DQQAAEERRRDFLQMVLDARH--------SASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMA 369

  Fly   307 -----DDLLAQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKPLDYDTL 366
                 |:::.|..:|..||:|.:...|||.:|.|..||:.|||||.|:...||:  ....::.:|
Human   370 RPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEK--HMAPEFCSL 432

  Fly   367 -MGMKYLNCVVSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNF 430
             .|:.||:.|::|:||.:||||...|....|.::..:      .:....::.:.||||||||:::
Human   433 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ------RIPAGAVLEMAVGALHHDPEHW 491

  Fly   431 PEPEQFRPERFDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLV--LRYHLKPTDRT 493
            |.||.|.||||..|.:.:.|.|||||||.|.|||:|.||.|:|||..:..::  .|:...|..:.
Human   492 PSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQV 556

  Fly   494 PADMMSSISGFRLLPRELFWCKLESR 519
            |..:.|..:   |.|:...:.|:.||
Human   557 PLQLESKSA---LGPKNGVYIKIVSR 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	CYP6-like	68..513	CDD:410679	151/535 (28%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	150/531 (28%)