DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9c1 and Cyp3a57

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001093650.1	Gene:	Cyp3a57 / 622127	MGIID:	3646373	Length:	503	Species:	Mus musculus

Alignment Length:	493	Identity:	153/493 - (31%)
Similarity:	250/493 - (50%)	Gaps:	55/493 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLLYKWSVYTFGYFSKRGVAHEKPIPLLGNI------PWSVLMGKESYIKHSIDLHLRLKQHKVY 73
            :..|.:..|:.|.|.|.|:...||:||.|||      .|.  ...:.|.|:.          |::
Mouse    20 VFFYIYGTYSHGLFKKLGIPGPKPLPLFGNIINYLDGMWK--FDDDCYKKYG----------KIW 72

  Fly    74 GVFNLRDPLYYLSDPELIRQVGIKN-FDTFTNHRKGITEGFNDTSVISKSLLSLRDRRWKQMRST 137
            |.:....|:..:.|||:|:.|.:|. :..|||.|.     |.....:.||:....|..||::|:.
Mouse    73 GFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRP-----FGPVGFLKKSITISEDEEWKRLRTL 132

  Fly   138 LTPTFTSLKIRQMFELIHFCNVEAVDFVQRQL---DAGTSELELKDFFTRYTNDVIATAAFGIQV 199
            |:|||||.|:::||.::.    :..|.:.|.|   :.....:.:||.|..|:.|||...:.|:.:
Mouse   133 LSPTFTSSKLKEMFPIMR----QYGDILVRNLRREEEKEEPINMKDIFGAYSMDVITGTSCGVNI 193

  Fly   200 NSFKDPNNEFFSIGQRISEFTFWGG--LKVMLYILMPKLMKALRVPVMDMNNVDYFKKLVFGAMK 262
            :|..:|.:.|....::|.:|.|:..  |.|:|:..:..:.:.|.:.:....::::|||.|....|
Mouse   194 DSLNNPQDPFVQKIKKILKFKFFDPFLLSVVLFPFLTPIYEMLNLSIFPRQSMNFFKKFVKKMKK 258

  Fly   263 YRKEQSIV-RPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQCLLFFSAGFETVAT 326
            .|.:.:.. |.|.:.|:|..|           .|..|:.....:|.::.||.|:|...|::..:|
Mouse   259 DRLDYNQKNRVDFLQLMMNTQ-----------NSKGQESLKALSDLEMAAQTLIFIFGGYDGTST 312

  Fly   327 CLSFTSYELMMNPEVQEKLLAEILAVKEQLGEK-PLDYDTLMGMKYLNCVVSESLRKWPPAFIVD 390
            .:||..|||..:|:||:||..||   ...|..| |:.||.||.|:||:.||:||||.:|....:|
Mouse   313 SISFIMYELATHPDVQKKLQDEI---DRALPNKAPVTYDALMDMEYLDMVVNESLRLYPVVSRID 374

  Fly   391 RMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEEHKHEIRQFTYL 455
            |....|.::..      |.:.:..:|.|.:..||.||:.:||||.|.||||.:|:|..|..:.|:
Mouse   375 RFSKKDVEIHG------VFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPERFSKENKGNIDPYIYM 433

  Fly   456 PFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRT 493
            |||.|.|:|||.|.||:.||..:..::..:.::|.:.|
Mouse   434 PFGNGPRNCIGMRFALISVKLAVTGVLQNFTVQPCEET 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	147/471 (31%)
Cyp3a57	NP_001093650.1	p450	39..493	CDD:278495	147/474 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770