DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9c1 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	494	Identity:	148/494 - (29%)
Similarity:	257/494 - (52%)	Gaps:	57/494 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLLYKWSVYTFGYFSKRGVAHEKPIPLLGNI------PWSVLMGKESYIKHSIDLHLRLKQHKVY 73
            :|.|.:..|:.|.|.|.|:...||:||||.|      .|.  ..::.|.|:.          |::
Mouse    20 VLFYIYGTYSHGLFKKLGIPGPKPLPLLGTIFNYYDGMWK--FDEDCYKKYG----------KIW 72

  Fly    74 GVFNLRDPLYYLSDPELIRQVGIKN-FDTFTNHRKGITEGFNDTSVISKSLLSLRDRRWKQMRST 137
            |.:....|:..:.|||:|:.|.:|. :..|||.|     .|.....:.|::....|..||::|:.
Mouse    73 GFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR-----FFGPVGFMKKAITISEDEEWKRLRTL 132

  Fly   138 LTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGTSELELKDFFTRYTNDVIATAAFGIQVNSF 202
            |:|||||.|:::||.::.......|..::|:.:.| ..:.:||.|..|:.|||...:||:.|:|.
Mouse   133 LSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKG-EPISMKDIFGAYSMDVITGTSFGVNVDSL 196

  Fly   203 KDPNNEFFSIGQRISEFTFWGG--LKVMLYILMPKLMKALRVPVMDMNNVDYFKKLVFGAMKYRK 265
            .:|.:.|....::|.:|..:..  |.::|:..:..:.:.|...:...:::::|||.|    |..|
Mouse   197 NNPQDPFVQKAKKILKFKIFDPFLLSIILFPFLTPIYEMLNFSIFPRDSMNFFKKFV----KRMK 257

  Fly   266 EQSIV-----RPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQCLLFFSAGFETVA 325
            ::.:.     |.|.:.|:|..|           .|..|:.:...:|.::.||.::|...|::..:
Mouse   258 KERLASNQKNRVDFLQLMMNTQ-----------NSKGQESQKALSDLEMAAQAVIFIFGGYDATS 311

  Fly   326 TCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEK-PLDYDTLMGMKYLNCVVSESLRKWPPAFIV 389
            |.:|...|||..:|:||:||..||   ...|..| |:.||.||.|:||:.||:||||.:|.|..:
Mouse   312 TSISLIMYELATHPDVQKKLQDEI---DRTLPNKAPVTYDALMDMEYLDMVVNESLRLYPIAIRL 373

  Fly   390 DRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEEHKHEIRQFTY 454
            :|:...|.::..      |.:.:..:|.|.:..||.:|:.:|||::|.||||.:|:|..|..:.|
Mouse   374 ERVSKKDVEING------VFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDPYIY 432

  Fly   455 LPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRT 493
            :|||.|.|:|||.|.||:.:|..:..::..:.::|.:.|
Mouse   433 MPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEET 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	141/472 (30%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	141/475 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770