DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9c1 and Cyp6a22

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	151/542 - (27%)
Similarity:	254/542 - (46%)	Gaps:	86/542 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IFVAFIGLLLYKWSVYT-FGYFSKRGVAHEKPIPLLGNIPWSVLMGKESY--IKHSID----LHL 65
            :.:..|.|.:..|.|.| :.|:::||:..|.....:||:        |.:  .||.||    ::.
  Fly     5 VALLLIALAVGFWFVRTRYSYWTRRGIGSEPARFPVGNM--------EGFRKNKHFIDIVTPIYE 61

  Fly    66 RLKQH--KVYGVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEGFNDTSVISKSLLSLRD 128
            :.|.:  ...|.|.:..|:..::|.||.:|:.|::|..|.:  :|:.....| ..::..|..:..
  Fly    62 KFKGNGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFED--RGMYHNERD-DPLTGHLFRIDG 123

  Fly   129 RRWKQMRSTLTPTFTSLKIRQMF--------ELIHFCNVEAVDFVQRQLDAGTSELELKDFFTRY 185
            .:|:.:|..::|||||.|::.||        ||...|. |..|      :|....||:.|...||
  Fly   124 PKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCG-ELAD------NAMCGILEIGDLMARY 181

  Fly   186 TNDVIATAAFGIQVNSFKDPNNEFFSIGQR--------------ISEFTFWGGLKVMLYILMPKL 236
            |:|||...|||::.|..::|..||..:|:|              |..|              |::
  Fly   182 TSDVIGRCAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIESF--------------PEV 232

  Fly   237 MKALRVPVMDMNNVDYFKKLVFGAMKYRKEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDK 301
            .:.||:..:..:..|::..:|...:|.|:||.|||.|.::||:|                 .:.:
  Fly   233 ARFLRMRQIHQDITDFYVGIVRETVKQREEQGIVRSDFMNLLIE-----------------MKQR 280

  Fly   302 AEFNDDDLLAQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEI-LAVKEQLGEKPLDYDT 365
            .|...:::.||..:||:|||:|.|:.|.|..|||...|.:|.||..|| .|::...||  ..||:
  Fly   281 GELTIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGE--FTYDS 343

  Fly   366 LMGMKYLNCVVSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNF 430
            :..::|:..|::|:|||:|   |:.::......|...:|:....:....::.|.|..:||||..:
  Fly   344 MQELRYMELVIAETLRKYP---ILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALY 405

  Fly   431 PEPEQFRPERFDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPA 495
            |||.:|.||||..:...:.....:||||.|.|:|||.|...|:....:..|:..:|.....||..
  Fly   406 PEPHKFIPERFLADQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDP 470

  Fly   496 DMMSSISGFRLLPRELFWCKLE 517
            .:....|...|.|....:.|::
  Fly   471 KIEFLKSNILLCPANGIYLKVQ 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	141/507 (28%)
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	141/509 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461215
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900