DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and Cyp3a73

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_038945885.1	Gene:	Cyp3a73 / 498198	RGDID:	1595705	Length:	504	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	159/529 - (30%)
Similarity:	283/529 - (53%)	Gaps:	61/529 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VELSIFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIK--HSIDLHLR 66
            :|..:.:|.|.:|.|::...|.|.|.|:|:...||:|.||.:        .:|.:  ...|:...
  Rat     9 LETWLLLAIILVLFYRFGTRTHGIFKKQGIPGPKPLPFLGTV--------LNYYRGLWKFDMECY 65

  Fly    67 LKQHKVYGVFNLRDPLYYLSDPELIRQVGIKN-FDTFTNHRKGITEGFNDTSVISKSLLSLRDRR 130
            .|..|::|:|:.:.|::.:.|.|:|:.|.:|. |..|||.|     ......::|||:...:|..
  Rat    66 KKCGKIWGLFDGQTPVFAIMDTEMIKSVLVKECFSVFTNRR-----NIGPVGIMSKSISVAKDEE 125

  Fly   131 WKQMRSTLTPTFTSLKIRQMFELI-HFCNVEAVDFVQRQLDAGTSELELKDFFTRYTNDVIATAA 194
            ||:.|:.|:|||||.::::||.:| |:.:: .|.:::::::.| ..|.:|:.|..|:.|||.:.:
  Rat   126 WKRYRAFLSPTFTSGRLKEMFPIIEHYGDI-LVKYLKQKVEKG-KPLAMKEVFGAYSMDVITSTS 188

  Fly   195 FGIQVNSFKDPNNEFFSIGQRISEFTFWGG--LKVMLYILMPKLMKALRVPVMDMNNVDYFKKLV 257
            |.:.:||..:|.:.|....::...|.|:..  |.|:|:..:..:.:.|.:.:...::|.:|:|.|
  Rat   189 FEVNINSINNPKDPFVEKVKKFQRFDFFDPLFLSVVLFPFLTPIYEMLNICLFPKDSVAFFQKFV 253

  Fly   258 FGAMKYRKEQSIV------RPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQCLLF 316
                 ||.:|:.:      |.|.:.|:|.|....|.:....|          .:|.:::||.::|
  Rat   254 -----YRMKQTRLDSKHKHRVDFLQLMMNAHNNSKDKVSHKA----------LSDIEIVAQAIIF 303

  Fly   317 FSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEK-PLDYDTLMGMKYLNCVVSESL 380
            ..|.:||.::.|||..|.|..:|:.|:||..||   ...|..| |..|||:|.|:||:.|::|:.
  Rat   304 IFASYETTSSTLSFVLYSLATHPDSQKKLQEEI---DRALPNKAPPTYDTVMEMEYLDMVLNETP 365

  Fly   381 RKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEEH 445
            |.:|..:.::|:|..|.:|   :|   |.:.:..:|.|....|.|||.::||||:|.||||.:|:
  Rat   366 RLYPIGYRLERVCKKDIKL---DG---VFIPKGSVVMIPFYTLQHDPQHWPEPEEFLPERFSKEN 424

  Fly   446 KHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPADMMSS---ISG---- 503
            |..|..:.|||||.|.|:|||.|.|||.:|..:.:::..:..:..:.|...:..|   :.|
  Rat   425 KGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQLCEETQIPLKLSRQRLFGPEKP 489

  Fly   504 --FRLLPRE 510
              .:::||:
  Rat   490 IVLKVVPRD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	149/496 (30%)
Cyp3a73	XP_038945885.1	CYP3A	67..493	CDD:410743	140/456 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010