DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and Cyp6a17

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	178/532 - (33%)
Similarity:	269/532 - (50%)	Gaps:	62/532 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LSIFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIPLLGNI-PWSVLMGKESYIKHSIDLHLRLK- 68
            |::.|..:.||::. :....||:.:||:.|::..||.||| .|.   .|....:...|.:.:.|
  Fly     4 LALIVVILSLLVFA-ARRRHGYWQRRGIPHDEVHPLFGNIKDWP---NKRHIAEIFRDYYFKYKN 64

  Fly    69 -QHKVYGVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEGFND-TSVISKSLLSLRDRRW 131
             .:...|.|........::|.||:::|.||:|:.|.|  :|:.  :|: ...:|.:|.|:..::|
  Fly    65 SDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFEN--RGVF--YNEIDDPLSATLFSIEGQKW 125

  Fly   132 KQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGT--SELELKDFFTRYTNDVIATAA 194
            :.:|..|||||||.|::.||.::.... |.:|.|.|...|..  ..||:.|...|||.|||...|
  Fly   126 RHLRHKLTPTFTSGKMKNMFPIVVKVG-EEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCA 189

  Fly   195 FGIQVNSFKDPNNEFFSIGQR-ISEFTFWGGLKVMLYILMPKLMKALRVPVMDMNNVDYFKKLVF 258
            ||:..||..||..||.|||:| |:|..:...|.:.|: ..|||.:.||:.:......|::.|:|.
  Fly   190 FGLNCNSLYDPKAEFVSIGKRAITEHRYGNMLDIFLF-GFPKLSRRLRLKLNIQEAEDFYTKIVR 253

  Fly   259 GAMKYRKEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQCLLFFSAGFET 323
            ..:.||......|.|.:..|:|   .:|.||.|::|     |...||  :||||..:||.|||||
  Fly   254 ETIDYRLRTKEKRNDFMDSLIE---MYKNEQSGNSE-----DGLTFN--ELLAQAFIFFVAGFET 308

  Fly   324 VATCLSFTSYELMMNPEVQEKLLAEILAVKEQLG------EKPLDYDTLMGMKYLNCVVSESLRK 382
            .:|.:.|..|||..|.:||:||       :|::|      .|...|:.:..||||..||.|:|||
  Fly   309 SSTTMGFALYELARNQDVQDKL-------REEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRK 366

  Fly   383 WPPAFIVDRMCGSDFQLKD-----EEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFD 442
            :|....:.||..:||..:|     .:|.:||         |....:|:|||.:||||.|:||||.
  Fly   367 YPVLAHLTRMTDTDFSPEDPKYFIAKGTIVV---------IPALGIHYDPDIYPEPEIFKPERFT 422

  Fly   443 EEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPADM--------MS 499
            :|........|:||||.|.|:|||.|..:|:....:..|:..|....:..|...|        :|
  Fly   423 DEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILIS 487

  Fly   500 SISGFRLLPREL 511
            :.:|..|...:|
  Fly   488 AENGIHLKVEKL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	169/501 (34%)
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	164/476 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461213
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800