DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9c1 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	223/524 - (42%)
Similarity:	329/524 - (62%)	Gaps:	21/524 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ELSIFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKHSIDLHLRLKQ 69
            |.....|....|.|:|:.....:|..||:|:|||:...||:. .:.:.|.:......||:.:...
  Fly     4 EFFALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMA-GMFLRKRAMFDIVCDLYTKGGS 67

  Fly    70 HKVYGVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEGFND-----TSVISKSLLSLRDR 129
            .|.:|:|..|.||..:.||:||:|:.||:||.|.|||.......:|     :::...||.|:||.
  Fly    68 KKFFGIFEQRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMRDA 132

  Fly   130 RWKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGT--SELELKDFFTRYTNDVIAT 192
            |||.|||||:|.||..|:||||:|::....||||.: :|.|:..  :||::||:.||:||||||:
  Fly   133 RWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCL-KQDDSRVQENELDMKDYCTRFTNDVIAS 196

  Fly   193 AAFGIQVNSFKDPNNEFFSIGQRISEFTFWGGLKVMLYILMPKLMKALRVPVMDMNNVDYFKKLV 257
            .|||:|||||||..|.|:.:|::::.|||...:|.||:..:..|.|.|:|.:.|..:..||.:||
  Fly   197 TAFGLQVNSFKDRENTFYQMGKKLTTFTFLQSMKFMLFFALKGLNKILKVELFDRKSTQYFVRLV 261

  Fly   258 FGAMKYRKEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQCLLFFSAGFE 322
            ..|||||:|.:|||||||::||||:...:.|:  :..||.:    |::|.|::|||.:||.||||
  Fly   262 LDAMKYRQEHNIVRPDMINMLMEARGIIQTEK--TKASAVR----EWSDRDIVAQCFVFFFAGFE 320

  Fly   323 TVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKPLDYDTLMGMKYLNCVVSESLRKWPPAF 387
            |.|..:.||::|||.|.:||::|..|:..|.:.|..|.|.|:.:||||||:.||:|.|||||.|.
  Fly   321 TSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGKELTYEAIMGMKYLDQVVNEVLRKWPAAI 385

  Fly   388 IVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEEHKHEIRQF 452
            .|||.|..|... |.:|: .|.:::.|::.:.....|.||..|..|.:|.||||.:|:|..|:.|
  Fly   386 AVDRECNKDITF-DVDGQ-KVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQPF 448

  Fly   453 TYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRT--PADMMSSISGFRLLPRELFWCK 515
            ||.|||:|||:|||:|.||:|.|::|:.|:..|...|..::  |.::::  |||:|.|:..||.|
  Fly   449 TYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELIT--SGFQLSPKGGFWIK 511

  Fly   516 LESR 519
            |..|
  Fly   512 LVQR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	209/485 (43%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	209/485 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469069
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D21895at7147
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
	12	11.830