DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9c1 and cyp4t8

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_954686.2	Gene:	cyp4t8 / 387527	ZFINID:	ZDB-GENE-031219-3	Length:	509	Species:	Danio rerio

Alignment Length:	553	Identity:	118/553 - (21%)
Similarity:	203/553 - (36%)	Gaps:	117/553 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVFVELSIFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIP------LLGNIPWSVLMGKESYIKH 59
            ::|  |:..:..:.||:.:          ::||...:..|      |.|::        :.:.:.
Zfish    19 LIF--LACLLTVVKLLIVR----------RKGVKTMERFPGPPAHWLFGHV--------KEFRQD 63

  Fly    60 SIDLHLRLKQHKVY------------GVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEG 112
            ..||...:|..::|            .|.|:..|.|            :|...|.|..:......
Zfish    64 GHDLEKIVKWMELYQFAFPLWFGPSLAVLNIHHPSY------------VKTILTTTEPKDDYAYK 116

  Fly   113 FNDTSVISKSLLSLRDRRWKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLD------A 171
            | ....:...||....::|.:.|..|||.|....::...:||.       |..:..||      .
Zfish   117 F-FIPWLGDGLLVSTGQKWFRHRRLLTPGFHYDVLKPYVKLIS-------DSTKVMLDKWEVHSR 173

  Fly   172 GTSELELKDFFTRYTNDVIATAAFGIQVNSFKDP-NNEFFSIGQRISEFTFWGGLKVMLYILMPK 235
            .....||....:..|.|.|...||....|...|. .|.:.   |.:.:......|:..::
Zfish   174 SEESFELFKHVSLMTLDSIMKCAFSCNSNCQTDSGTNPYI---QAVFDLCHLVNLRFRVF----- 230

  Fly   236 LMKALRVPVMDMNNVDYFKKLVF----GAMKYRKEQSIVRPDMIHLLMEAQRQFKAEQE-GSAE- 294
                           .|..|.:|    ...::||..||.......::.:.:...|.|:| |..:
Zfish   231 ---------------PYHSKAIFHLSPHGYRFRKAASIAHNHTAEVIRKRKEVLKMEEEQGIVKN 280

  Fly   295 -----------SAAQQDKAEFNDDDLLAQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAE 348
                       ||..:.:...:|:|:.|:...|...|.:|.|:.:|:..|.|..|||.|||...|
Zfish   281 RRYLDFLDILLSARDEHQQGLSDEDIRAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCRQE 345

  Fly   349 ILAVKEQLGEKPLDYDTLMGMKYLNCVVSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLRED 413
            |....:  |:..|:::.|..:.|....:.||||..||...:.|.........|  |..|   .|.
Zfish   346 IQQALD--GKATLEWEDLNKIPYTTMCIKESLRLHPPVPGISRKLTKPLTFFD--GRTV---PEG 403

  Fly   414 DLVHINVGALHHDPDNFPEPEQFRPERFDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLI 478
            ..:.:::..:|.:...:..|.:|.|.||..|:........::||..|.|:|||...|:.|:|..:
Zfish   404 CTIGVSIYGIHMNSTVWENPYKFDPLRFLPENVANRSPHAFVPFSAGPRNCIGQNFAMNEMKVAV 468

  Fly   479 FQLVLRYHL-KPTDRT----PADMMSSISGFRL 506
            ...:.||:| |..|.|    |..::.|::|..:
Zfish   469 ALTLKRYYLIKDPDHTPKMIPQVVLRSLNGIHI 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	112/517 (22%)
cyp4t8	NP_954686.2	p450	46..501	CDD:306555	112/512 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900