DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9c1 and Cyp6d2

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	144/509 - (28%)
Similarity:	256/509 - (50%)	Gaps:	51/509 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LSIFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVL---MGKESYIKHSI-DLHLR 66
            |:|.:|.   |||::....:.::.:.|| .|:|    ..||:.|:   |.:|..:..:: |::.|
  Fly     6 LTILIAG---LLYRYVKRHYTHWQRLGV-DEEP----AKIPFGVMDTVMKQERSLGMALADIYAR 62

  Fly    67 LKQHKVYGVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEGFNDTSVISKSLLSLRDRRW 131
             .:.|:.|::.|......:.|.:|.||:...:|.:|  |.:|:... .|...:|.:|.:||...|
  Fly    63 -HEGKIVGIYMLNKRSILIRDAQLARQIMTSDFASF--HDRGVYVD-EDKDPLSANLFNLRGASW 123

  Fly   132 KQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGTSELELKDFFTRYTNDVIATAAFG 196
            :.:|..|||:|:|.||:.||..|.....:.|..::..||. :.|:|:||..|.|..|:|.:..||
  Fly   124 RNLRQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQ-SDEVEIKDVMTTYAVDIIGSVIFG 187

  Fly   197 IQVNSFKDPNNEFFSIGQRIS--EFTFWGGLKV--MLYILMPKLMKALRVPVMDMNNVDYFKKLV 257
            ::::||::|.|||..|....|  |...   ||:  |...:.|.:.|.       ||.:.|..:::
  Fly   188 LEIDSFRNPKNEFREISSSTSRDESLL---LKIHNMSMFICPPIAKL-------MNRLGYESRIL 242

  Fly   258 FG-------AMKYRKEQSIVRPDMIHLLMEAQRQFKA----EQEGSAESAAQQDKAEFNDDDLLA 311
            ..       .:::|:|.::||.||:.||:..:...|.    :|....|:|.:|.|: .:.:.:.|
  Fly   243 TSLRDMMKRTIEFREEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKS-MSIEKIAA 306

  Fly   312 QCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKPLD---YDTLMGMKYLN 373
            |..||:.||.|:.|...:||.|||.|.||:.::...|:.||..:...||.|   |:.:..:|:|:
  Fly   307 QAFLFYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLD 371

  Fly   374 CVVSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRP 438
            ..:.|::||:|....::|.|..|:.:......:.    :...:.|::..:..||..||.|..:.|
  Fly   372 ICIMETIRKYPGLPFLNRECTEDYPVPGTNHIIA----KGTPILISLFGMQRDPVYFPNPNGYDP 432

  Fly   439 ERFDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDR 492
            .|||..:.: ..|..|:|||.|.|.||..|:..:..|..:.:::..:.|..:.|
  Fly   433 HRFDSNNMN-YDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPR 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	135/478 (28%)
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	127/441 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461135
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900