DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and Cyp6a21

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	144/531 - (27%)
Similarity:	251/531 - (47%)	Gaps:	51/531 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VELSIFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIPLLGNIP-----------WSVLMGKESYI 57
            |.|:..:|.:|.||.||. .|..::...|:..|:|..|:|::.           |:      ||
  Fly     6 VLLTALLALVGYLLMKWR-STMRHWQDLGIPCEEPHILMGSMKGVRTARSFNEIWT------SY- 62

  Fly    58 KHSIDLHLRLKQHKVY-GVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEGF---NDTSV 118
                  :.:.:....: |.:..|.|..::.:..|.:|:.||.|:.||:      .||   .:...
  Fly    63 ------YNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKEFNKFTD------RGFFHNPEDDP 115

  Fly   119 ISKSLLSLRDRRWKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGTSELELKDFFT 183
            :|..|..|..::|:.||:.|:.||||.|::.||..:.....|..| |..|..|.:..:|:::...
  Fly   116 LSGQLFLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTD-VFGQNVAKSPVVEVRELLA 179

  Fly   184 RYTNDVIATAAFGIQVNSFKDPNNEFFSIGQRISEFTFWGGLKVMLYILMPKLMKALRVPVMDMN 248
            |:|.|||.|.||||:.:|.|||:.||..:|:|.......|.:.:......|.|.:.|.:.:....
  Fly   180 RFTTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLARRLHMKMTAEP 244

  Fly   249 NVDYFKKLVFGAMKYRKEQSIVRPDMIHLLMEAQ-RQFKAEQEGSAESAAQQDKAEFNDDDLLAQ 312
            ...:|.::|...:.:|::.:|.|.|.:..|::.: :.....|.|        :......:::.||
  Fly   245 IERFFMRIVRETVAFREQNNIRRNDFMDQLIDLKNKPLMVSQSG--------ESVNLTIEEIAAQ 301

  Fly   313 CLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQL-GEKPLDYDTLMGMKYLNCVV 376
            ..:||:|||||.:|.:.|..|||..|.::|.::..|...|.|:. ||  |:|:::..:.||:.||
  Fly   302 AFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGE--LNYESMKDLVYLDQVV 364

  Fly   377 SESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERF 441
            ||:||.:....:::|.|..|:::......|:   ::...|.|..||:|.|...:..|..|.|:.|
  Fly   365 SETLRLYTVLPVLNRECLEDYEVPGHPKYVI---KKGMPVLIPCGAMHRDEKLYANPNTFNPDNF 426

  Fly   442 DEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPADMMSSISGFRL 506
            ..|...|.....:||||.|.|:|||.|...|:.:..:..|:..:.....::|...|..:...|.:
  Fly   427 SPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFLI 491

  Fly   507 LPRELFWCKLE 517
            ......:.|.|
  Fly   492 ASNSGIYLKAE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	131/493 (27%)
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	132/496 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461207
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800