DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9c1 and Cyp6a20

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	159/522 - (30%)
Similarity:	261/522 - (50%)	Gaps:	52/522 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IFVAFIGLLLY-KWSVYT-FGYFSKRGVAHEKPIPLLGNIPWSVLMG--------KESYIKHSID 62
            :.|..||::.: .|.|:. |.|:.:||:.|::|....||.  |.||.        |.:|.|
  Fly     4 MIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNT--SELMKTVHFADIFKRTYNK---- 62

  Fly    63 LHLRLKQHKVY-GVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEGFNDTSVISKSLLSL 126
              ||.|....: |.:.....:..::|.:..:.|.|:.||.|  |.:|:.....| ..:|.:|:::
  Fly    63 --LRNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKF--HDRGVFHNERD-DPLSANLVNI 122

  Fly   127 RDRRWKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGTSELELKDFFTRYTNDVIA 191
            ..::||.:|..|||||||.|::.||..|.....|.:........|.:..:|:.:...|:|.|||.
  Fly   123 DGQKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIG 187

  Fly   192 TAAFGIQVNSFKDPNNEFFSIG-QRISEFTFWGGLKVMLYILMPKLMKALRVPVMDMNNVDYFKK 255
            :.|||:..:|..||..:|..:| ..|:|......:.::|: ..|:|...||:........|::..
  Fly   188 SCAFGLDCHSLSDPKAKFVQMGTTAITERRHGKSMDLLLF-GAPELAAKLRMKATVQEVEDFYMN 251

  Fly   256 LVFGAMKYRKEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQCLLFFSAG 320
            ::...:.||.:.::.|.|.:.:|:|.:.:|        ::..:::...||  ::.||..:||.||
  Fly   252 IIRDTVDYRVKNNVKRHDFVDMLIEMKLKF--------DNGDKENGLTFN--EIAAQAFIFFLAG 306

  Fly   321 FETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKPLDYDTLMGMKYLNCVVSESLRKWPP 385
            |||.:|.:.|..|||..:.::|:||..||..|.:|...| ||||::..|.||..|:.|::||.|.
  Fly   307 FETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGK-LDYDSMREMTYLEKVIDETMRKRPV 370

  Fly   386 AFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEEHKHEIR 450
            ...:.|:....:|..:.:    .|:.:...|.:...|:||||:.:||||:|.||||||:...:..
  Fly   371 VGHLIRVATQHYQHTNPK----YNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQRP 431

  Fly   451 QFTYLPFGVGQRSCIGNRLALMEV----KSLIFQLVLRYHLKPTD-------RTPADMMSSISGF 504
            ..|:||||.|.|:|||.|...|:|    ..||......:|  ||.       ||...::||..|.
  Fly   432 ACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFH--PTKTVVPLEYRTDDFLLSSKGGI 494

  Fly   505 RL 506
            .|
  Fly   495 HL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	149/491 (30%)
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	149/492 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.870