DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and Cyp6a13

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	165/530 - (31%)
Similarity:	273/530 - (51%)	Gaps:	63/530 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LSIFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKHSIDLHLRLKQ- 69
            |.:.|..:|||||....:.:.|:|:||||.|:|:...||:..   :|::   .|..|::||:.:
  Fly     4 LLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSG---LGRD---LHWTDINLRIYRK 62

  Fly    70 ----HKVYGVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEGFNDTSVISKSLLSLRDRR 130
                .:..|.|.......::.|.||||.:.|::|.:|.:  :|:.....| ..::.:||.|....
  Fly    63 FRGVERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFAD--RGLFHNVRD-DPLTGNLLFLDGPE 124

  Fly   131 WKQMRSTLTPTFTSLKIRQMF--------ELIHFCNVEAVDFVQRQLDAGTSELELKDFFTRYTN 187
            |:.:|..||..|||.|::.||        :|...|.::            ..|:|.||...|:|.
  Fly   125 WRWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQ------------VGEIEAKDLCARFTT 177

  Fly   188 DVIATAAFGIQVNSFKDPNNEFFSIGQRISEFTFWGGLKVMLYILMPKLMKALRVPVMDMNNVDY 252
            |||.:.|||::.||.:||.::|..:|:.:::......|........|:|.:.||..:......::
  Fly   178 DVIGSCAFGLECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEF 242

  Fly   253 FKKLVFGAMKYRKEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQCLLFF 317
            |...|...:.||:.::|.|.|:|.||||      ..:||      .:|...|  :.:.||.|:||
  Fly   243 FLDTVRQTLDYRRRENIHRNDLIQLLME------LGEEG------VKDALSF--EQIAAQALVFF 293

  Fly   318 SAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKPLDYDTLMGMKYLNCVVSESLRK 382
            .|||:|.:|.:||..|||.:||:|||:|..|:|||.::..:| |.||::..|.||:.||:|:|||
  Fly   294 LAGFDTSSTTMSFCLYELALNPDVQERLRVEVLAVLKRNNQK-LTYDSVQEMPYLDQVVAETLRK 357

  Fly   383 WPPAFIVDRMCGSDFQLKD-----EEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFD 442
            :|....:.|....::|:.:     |.|..::         |.|.::||||:.:|:||:|.|.||:
  Fly   358 YPILPHLLRRSTKEYQIPNSNLILEPGSKII---------IPVHSIHHDPELYPDPEKFDPSRFE 413

  Fly   443 EEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPADMMSSISGFRLL 507
            .|.......|.|||||.|.|:|||.|...::||..:..|:..:....:::|...:..|...|.:.
  Fly   414 PEEIKARHPFAYLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLIS 478

  Fly   508 PRELFWCKLE 517
            .:|....::|
  Fly   479 TQEGVHLRME 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	150/494 (30%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	149/487 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461216
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800