DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and Cyp6a14

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	527	Identity:	164/527 - (31%)
Similarity:	264/527 - (50%)	Gaps:	43/527 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VAFIGLLL---YKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKHSIDLHLRLKQHK 71
            :|.:|::|   |...:..|.|:.::||.||.|:|::||:...|    :.|       |.|....:
  Fly     5 IALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIV----KKY-------HFRDINQR 58

  Fly    72 VYGVFNLRDPL----------YYLSDPELIRQVGIKNFDTFTNHRKGITEGFNDTSVISKSLLSL 126
            :|..|..:.|:          ..::|.:.|:||.||:|..|.: |...|...:|.  ::..|.:|
  Fly    59 IYKKFKGQGPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQD-RGAFTNPRDDP--LTGHLFAL 120

  Fly   127 RDRRWKQMRSTLTPTFTSLKIRQMFELIHFCNV---EAVDFVQRQLDAGTSELELKDFFTRYTND 188
            ....|:.||..|||.|||.||:||.::|....:   :|:|...::.......:|:||...|:|.|
  Fly   121 EGEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTD 185

  Fly   189 VIATAAFGIQVNSFKDPNNEFFSIGQRISEFTFWGGLKVMLYILMPKLMKALRVPVMDMNNVDYF 253
            ||.:.|||::.||.:||:.||...|:.|........|.........:|.:.||:.|:..:...:|
  Fly   186 VIGSCAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNARLARKLRIKVLPDDLTQFF 250

  Fly   254 KKLVFGAMKYRKEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAE-FNDDDLLAQCLLFF 317
            ...|...:.||.:..|.|.|.|..::|    .:||.:.:|:.....|.:. ...:.:.||..:||
  Fly   251 MSTVKNTVDYRLKNGIKRNDFIEQMIE----LRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFF 311

  Fly   318 SAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKPLDYDTLMGMKYLNCVVSESLRK 382
            .|||||.::.:|...|||.:.|::|::|..||.:|...:....|:||.|..|.||:.|:||:|||
  Fly   312 VAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRK 376

  Fly   383 WP--PAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEEH 445
            .|  |..|  |....|:|:.:.:    :.|.:..|..|.|..:||||:.:||||:|.|.|||.|.
  Fly   377 HPLLPHLI--RETTKDYQIPNSD----IVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEE 435

  Fly   446 KHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPADMMSSISGFRLLPRE 510
            ........|||||.|.|:|||.|...::.|..:..|:.|:....::||...::.|...|.|...:
  Fly   436 VKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTND 500

  Fly   511 LFWCKLE 517
            ..:.|:|
  Fly   501 GIYLKVE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	152/492 (31%)
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	154/497 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
	10	10.000