DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and Cyp9b2

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	225/534 - (42%)
Similarity:	326/534 - (61%)	Gaps:	45/534 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVFVELSIFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKHSIDLHL 65
            |..:|:.:.:..||.|:||||..||..|.:|.:..|||.|.:||:..:.|. |.|:.:...:.:.
  Fly     1 MALIEICLALVVIGYLIYKWSTATFKTFEERKLYFEKPYPFVGNMAAAALQ-KSSFQRQLTEFYE 64

  Fly    66 RLKQHKVYGVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEG---FNDTSVISKSLLS-L 126
            |.:|||:.|.||:|.|:..|:|||||::|.:|:||.|.||:..||..   |||       :|| :
  Fly    65 RTRQHKLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFITSNDRLFND-------MLSVM 122

  Fly   127 RDRRWKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGTS--------ELELKDFFT 183
            ||:|||.||:||||.||:.|:|.||.|::....|.:    :.||:.:.        |:::|....
  Fly   123 RDQRWKHMRNTLTPVFTAAKMRNMFTLMNESFAECL----QHLDSSSKTLPGRKGFEVDMKVMCN 183

  Fly   184 RYTNDVIATAAFGIQVNSFKDPNNEFFSIGQRISEFTFWGGL---KVMLYILMPKLMKALRVPVM 245
            :.:||:|||.|||::|||:.:|.|||:.|||.:   .|..||   |.||..|:|||...|::.:.
  Fly   184 KLSNDIIATTAFGLKVNSYDNPKNEFYEIGQSL---VFSRGLQFFKFMLSTLVPKLFSLLKLTIF 245

  Fly   246 DMNNVDYFKKLVFGAMKYRKEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLL 310
            |...||||.:||..||:||::.:|.|||||.|||||:.:             .:||  :.||:::
  Fly   246 DSAKVDYFARLVVEAMQYREKHNITRPDMIQLLMEAKNE-------------SEDK--WTDDEIV 295

  Fly   311 AQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKPLDYDTLMGMKYLNCV 375
            |||.:||.|.||..:..:..|:|||:.||:|||:|..||:..|:.|...||.||.:..|.|::.|
  Fly   296 AQCFIFFFAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMV 360

  Fly   376 VSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPER 440
            :|||||||..|...||:|..|:.|.|::|..:.:.:..|.::|.:..||.|...||||.:|.|:|
  Fly   361 ISESLRKWTLAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDR 425

  Fly   441 FDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPADMMSSISGFR 505
            |.||.|.::..:||||||||.|:|||||.|||:||.::|.|:|.|.::.:.||..|:..|.|||.
  Fly   426 FSEERKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASPRTIKDLWGSASGFN 490

  Fly   506 LLPRELFWCKLESR 519
            ..||..||..|..|
  Fly   491 FTPRSGFWMHLVPR 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	208/491 (42%)
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	198/470 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469074
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	1	1.000	-	-		H133568
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	12	11.800