DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and Cyp9b1

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	215/526 - (40%)
Similarity:	324/526 - (61%)	Gaps:	29/526 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVFVELSIFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKHSIDLHL 65
            |.|||:.:.:|.|||||:|||..||..|..|.:..|||.|.|||:..|.|. |.|:.|...:.:.
  Fly     1 MSFVEICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQ-KASFQKQISEFYN 64

  Fly    66 RLKQHKVYGVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEGFNDTSVISKSLLSLRDRR 130
            |.:.||:.|:||||.|:..::||:||:::.:|:||.|.||:   |....:..:::..|..:||:.
  Fly    65 RTRHHKLVGLFNLRTPMIQINDPQLIKKICVKDFDHFPNHQ---TLNIPNERLVNDMLNVMRDQH 126

  Fly   131 WKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQ--RQLDAGTS--ELELKDFFTRYTNDVIA 191
            |:.|||.|||.|||.|:|.||.|::....:.::.::  :.:.||.:  ||::|....:.:|||||
  Fly   127 WRNMRSVLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSNDVIA 191

  Fly   192 TAAFGIQVNSFKDPNNEFFSIGQRISEFTFWGG---LKVMLYILMPKLMKALRVPVMDMNNVDYF 253
            |.|||::||||.||.|||.:||:.::   |..|   ||.|:.:|.||:....::.:.|..||:||
  Fly   192 TTAFGLKVNSFDDPENEFHTIGKTLA---FSRGLPFLKFMMCLLAPKVFNFFKLTIFDSTNVEYF 253

  Fly   254 KKLVFGAMKYRKEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQCLLFFS 318
            .:||..||:||::.:|.|||||.|||||::               :.|..:.||:::|||.:||.
  Fly   254 VRLVVDAMQYREKHNITRPDMIQLLMEAKK---------------ESKDNWTDDEIVAQCFIFFF 303

  Fly   319 AGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKPLDYDTLMGMKYLNCVVSESLRKW 383
            |.||..:..:..|:|||:.|.::||:|..|:...:|.|...||.||....|.|::.|:|||||||
  Fly   304 AAFENNSNLICTTAYELLRNLDIQERLYEEVKETQEALKGAPLTYDAAQEMTYMDMVISESLRKW 368

  Fly   384 PPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEEHKHE 448
            ..:...||:|..|:.|.|:||..:...:..|.::|.:..||.|...||:|::|.||||.|..|.:
  Fly   369 TLSAAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKD 433

  Fly   449 IRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPADMMSSISGFRLLPRELFW 513
            :..:||||||||.|||||||.|:|:.|.:::.|:|.|.::.:.||..||..|..||.::|...||
  Fly   434 LIPYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRTTRDMWESARGFNIIPTTGFW 498

  Fly   514 CKLESR 519
            .:|.||
  Fly   499 MQLVSR 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	193/483 (40%)
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	184/462 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469073
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	1	1.000	-	-		H133568
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	12	11.800