DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9c1 and Cyp6w1

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	151/498 - (30%)
Similarity:	256/498 - (51%)	Gaps:	31/498 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LSIFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKHSIDLHLR--LK 68
            |.:.:..:.::.|.|...|..::.:.||.:.:|.|::| .....|..|..:.:.....|..  .:
  Fly     3 LLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVG-CTREFLTAKVPFFEQIQKFHEAPGFE 66

  Fly    69 QHKVYGVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEGFNDTSVISKSLLSLRDRRWKQ 133
            .....||:....|...:.|.|||:.|.||.|..| |:|...|:..|| ::..|:|...|...|::
  Fly    67 NEPFVGVYMTHRPALVIRDLELIKTVMIKKFQYF-NNRVLQTDPHND-ALGYKNLFFARSPGWRE 129

  Fly   134 MRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGTSELELKDFFTRYTNDVIATAAFGIQ 198
            :|:.::|.|||.||:||:.|:........|..:| |.:|| |:::||..:|:|.|:|||.|||::
  Fly   130 LRTKISPVFTSGKIKQMYPLMVKIGKNLQDSAER-LGSGT-EVQVKDLCSRFTTDLIATIAFGVE 192

  Fly   199 VNSFKDPNNEFFSIGQRISEFTFWGGLKVMLYILMPKLMKALRVPVMDMNNVDYFKKLVFGAMKY 263
            .|:.:|..:|||...:.|...|...|:...:..::|.|....||.:.......:.:..|...:|.
  Fly   193 ANALQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMIPALASLARVKLFSRETTKFIRSSVNYVLKE 257

  Fly   264 RKEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDK--AEFNDDDLLAQCLLFFSAGFETVAT 326
            |:.....|.|:|.:|:..:|          |:||...|  .|.:.|.|:||..:|.:|||||.|:
  Fly   258 RERTGEKRNDLIDILLALKR----------EAAANPGKMSKEVDLDYLVAQAAVFQTAGFETSAS 312

  Fly   327 CLSFTSYELMMNPEVQEKLLAEILAVKEQLG-EKPLDYDTLMGMKYLNCVVSESLRKWPPAFIVD 390
            .::.|.|||..|..:|::|..||:   :..| |..:.|:.:..|.||:.||:|:|||:|....::
  Fly   313 TMTMTLYELAKNEALQDRLRQEIV---DFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIE 374

  Fly   391 RMC-----GSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEEHKHEIR 450
            |.|     |..|.|:....   :.|.....::::..|:|.||..:|:||::.||||:..::..:.
  Fly   375 RECSQPAEGERFTLEPFHN---MELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLN 436

  Fly   451 QFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRT 493
            ...|:|||||.|:|||.||.|::.|..:..::..:.....|:|
  Fly   437 MDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKT 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	145/467 (31%)
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	145/467 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461057
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
	12	11.830