DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and Cyp310a1

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_609891.1	Gene:	Cyp310a1 / 35115	FlyBaseID:	FBgn0032693	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	119/560 - (21%)
Similarity:	243/560 - (43%)	Gaps:	137/560 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLLYK---WSV-YTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESY---IKH--SIDLHLRLKQH 70
            :|||.   .|| :.:.::.:||...||     ..|.||.|  :::|   .:|  :|....:..:.
  Fly     7 ILLYSAVFLSVRHIYSHWRRRGFPSEK-----AGITWSFL--QKAYRREFRHVEAICEAYQSGKD 64

  Fly    71 KVYGVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEGFNDTSVISKSLLSLRDRRWKQMR 135
            ::.|::....|:..:.:.||.:.:..::...|:..:.....|:...:::.|
  Fly    65 RLLGIYCFFRPVLLVRNVELAQTILQQSNGHFSELKWDYISGYRRFNLLEK-------------- 115

  Fly   136 STLTPTFTSLKIRQMF--------ELIHFCNVEAVDFVQRQLDAGTSELELKDFFTRYTNDVIAT 192
              |.|.|.:.::.:||        .|||       ..:.||......|::::.....|:.::||.
  Fly   116 --LAPMFGTKRLSEMFGQVQKVGDHLIH-------HLLDRQGQGCPQEVDIQQKLRVYSVNIIAN 171

  Fly   193 AAFGIQVNSFKDPNN---EFFSIGQ-RISEFTFWGGLKVMLYILMPKLMKALRVPVMDMNNVDY- 252
            ..:|:.:|:|:..::   .:.|..| .|..||..                  |:|  ..::..|
  Fly   172 LIYGLDINNFEHEDHILTSYLSHSQASIQSFTLG------------------RLP--QKSSYTYR 216

  Fly   253 FKKLVFGAMKYRKEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLL------- 310
            .:.|:..:::.|::..::|.|::.||:    :|:   .|:..|..:......||.|.|
  Fly   217 LRDLIKQSVELREDHGLIRKDILQLLV----RFR---NGNEVSGDKWQLEPINDADKLLSIKRLA 274

  Fly   311 --AQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKPLDYDTLMGMKYLN 373
              |:.||  ....:.||:.::||..|::..|.:.|||.|||..:..:.|:  |.::.|.|::|::
  Fly   275 KVAEDLL--KVSLDAVASTVTFTLLEILQEPLIVEKLRAEIKELSNENGQ--LKFEELNGLRYMD 335

  Fly   374 CVVSESLRKWPPAFIVDRMCGSDFQLKD-----EEGEVVVNLREDDLVHINVGALHHDPDNFPEP 433
            ..:.|:|||:||..|::|:|...:.|.:     :||:.::         :.:.|:|.|...|.||
  Fly   336 MCLKETLRKYPPLPIIERVCRKSYSLPNSKFTIDEGKTLM---------VPLLAMHRDEKYFSEP 391

  Fly   434 EQFRPERF----------DEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLK 488
            .:::|.||          :::.|..:    ::.||:|...|:|...|.:.:|..:.:|:..:||:
  Fly   392 MKYKPLRFLQTANDVGQCEDKTKSNV----FIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLE 452

  Fly   489 ---------PTDRTPADMMSSISGFRLLPRELFWCKLESR 519
                     .....||..:.:..|.::        ||:.|
  Fly   453 LDANQVKTLKVSHRPAPFIHTKDGLKV--------KLKRR 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	108/527 (20%)
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	96/451 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461153
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	7	6.850