DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9c1 and Cyp3a44

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_796354.1	Gene:	Cyp3a44 / 337924	MGIID:	2449818	Length:	504	Species:	Mus musculus

Alignment Length:	538	Identity:	164/538 - (30%)
Similarity:	285/538 - (52%)	Gaps:	71/538 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VFVELS----IFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIPLLGNI------PWSVLMGKESY 56
            :|..||    :.:|.|.:|||::...|.|.|.|:|:...||:|.||.:      .|...|  |.|
Mouse     3 LFSALSLDTLVLLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNYYTGIWKFDM--ECY 65

  Fly    57 IKHSIDLHLRLKQHKVYGVFNLRDPLYYLSDPELIRQVGIKN-FDTFTNHRKGITEGFNDTSVIS 120
            .|:.          |.:|:|:.:.||..::|||.|:.|.:|: ...|||.|:     |....::|
Mouse    66 EKYG----------KTWGLFDGQTPLLVITDPETIKNVLVKDCLSVFTNRRE-----FGPVGIMS 115

  Fly   121 KSLLSLRDRRWKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGTSELELKDFFTRY 185
            |::...:|..||:.|:.|:|||||.::::||.:|.......|.:::::.:.| ..:.:||....|
Mouse   116 KAISISKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEAEKG-MPVAMKDVLGAY 179

  Fly   186 TNDVIATAAFGIQVNSFKDPNNEFFSIGQRISEFTFWGGL--KVMLYILMPKLMKALRVPVMDMN 248
            :.|||.:.:||:.|:|..:|.:.|....::.....|:..|  .|:|:.|:..:.:.|.:.:...:
Mouse   180 SMDVITSTSFGVNVDSLNNPEDPFVEEAKKFLRVDFFDPLLFSVVLFPLLTPVYEMLNICMFPND 244

  Fly   249 NVDYFKKLVFGAMKYRKEQSIV-RPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQ 312
            ::::|||.|....:.|.:.:.. |.|.:.|:|.:....|.:....|          |::.::..|
Mouse   245 SIEFFKKFVDRMQESRLDSNQKHRVDFLQLMMNSHNNSKDKDSHKA----------FSNMEITVQ 299

  Fly   313 CLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKPL------DYDTLMGMKY 371
            .::|.|||:||.::.||||.|.|..:|::|:||.|||        :|.|      ..||:|.|:|
Mouse   300 SIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEI--------DKALPNKATPTCDTVMEMEY 356

  Fly   372 LNCVVSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQF 436
            |:.|::|:||.:|....::|:|..|.:|..      |.:.:..:|.|...||||||.::|:||:|
Mouse   357 LDMVLNETLRLYPIVTRLERVCKKDVELNG------VYIPKGSMVMIPSYALHHDPQHWPDPEEF 415

  Fly   437 RPERFDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPADMMSSI 501
            :||||.:|:|..|..:.|||||:|.|:|||.|.|||.:|..:.:::..:..:|...|...:..|.
Mouse   416 QPERFSKENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPLKLSR 480

  Fly   502 SG---------FRLLPRE 510
            .|         .:::||:
Mouse   481 QGILQPEKPIVLKVVPRD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	151/499 (30%)
Cyp3a44	NP_796354.1	p450	39..494	CDD:278495	149/496 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133568
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800