DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and Cyp309a1

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	135/532 - (25%)
Similarity:	226/532 - (42%)	Gaps:	60/532 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKHSIDLHLRLK-QHK 71
            :.|||  .::|.:..:...|:.||||...:|:.:||:.|..::....|.|....|::.:.| :::
  Fly    12 VHVAF--AVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYNKYKDKYR 74

  Fly    72 VYGVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEGF-----NDTSVISKSLLSLRDRRW 131
            ..|.|..|.|...:.||.|..::.:   |.|::.|..||..|     :|..|......|..| :|
  Fly    75 TVGTFITRQPQLLVLDPALAHEILV---DKFSHFRDTITSSFVGHNPDDKYVAGSPFFSAGD-KW 135

  Fly   132 KQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGTSELELKDFFTRYTNDVIATAAFG 196
            |::||......|..:::..:.:......:.|::::|........:|.:|...|:|.:.:|...:|
  Fly   136 KRLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDIIETRDLAYRFTANAMADFIWG 200

  Fly   197 IQVNSFKDPNNEFFSIGQRISEFTFWGGLKVMLYILMPKLMKALRV-PVMDMN-----NVDYFKK 255
            |...|......|   ||......|.|........|...|.:.|:.| .:..|.     ..::|.:
  Fly   201 IDAGSLSGKVGE---IGDFQKTSTDWSAHAFSSMIRFNKTLVAIFVRKLFSMRFFTKATDEFFLR 262

  Fly   256 LVFGAMKYRKEQS-IVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQCLLFFSA 319
            |...|:..|:..| ..|.|.:..|::.|      |.|:            :..|.:...|.....
  Fly   263 LTQDAVNLRQGGSGEGRTDYLSHLIQLQ------QRGN------------SIHDSVGHALTVHLD 309

  Fly   320 GFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKPLDYDTLMGMKYLNCVVSESLRKWP 384
            ||||....|....|.|..:.|.||||.:|||......|:  :.||.:..:.||:...:||||...
  Fly   310 GFETSGAVLYHMLYSLSEHHEEQEKLRSEILEALASEGQ--ISYDQINNLPYLDQCFNESLRLTT 372

  Fly   385 PAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGA--------LHHDPDNFPEPEQFRPERF 441
            |.....|:|....|         :||.:|..:.:..|.        .|||.|.:||..:|||:||
  Fly   373 PIGFFMRICTKPTQ---------INLGDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRF 428

  Fly   442 DEEHKHEI-RQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPADMMSSISGFR 505
            :......: ::..:||||.|.|.|:|.|:..:.||:.|..::..|.::...:.|....|.:..|.
  Fly   429 ENGAASVLTKRGCFLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVEQMKKVPLGADSGMGIFL 493

  Fly   506 LLPRELFWCKLE 517
            ....||.:.||:
  Fly   494 NGDVELKYTKLQ 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	124/498 (25%)
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	115/467 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460907
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.000