DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and Cyp6v1

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	157/541 - (29%)
Similarity:	273/541 - (50%)	Gaps:	62/541 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVFVELSIFVAFIGLL--LYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKHSIDL 63
            ||: ..:|.:|.:.:|  ::.||..|:.|:.:|.|...:|..||||:. .||..:||:   ::.|
  Fly     1 MVY-STNILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLS-RVLRLEESF---ALQL 60

  Fly    64 HL-----RLKQHKVYGVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEGFNDTSVISKSL 123
            ..     |.:...|.|::....|...:.|.:|:|.|.:::|.:|:| |....:|.:| .:.:.||
  Fly    61 RRFYFDERFRNEPVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSN-RFAKCDGRSD-KMGALSL 123

  Fly   124 LSLRDRRWKQMRSTLTPTFTSLKIRQMFELIH--FCNVE-AVDFVQRQLDAGTSE----LELKDF 181
            ...:...|:::|:.|.|.|...|::|||.|:.  .|::| .:..:.|.|..|.:|    :.:||.
  Fly   124 FLAKQPEWREIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDV 188

  Fly   182 FTRYTNDVIATAAFGIQVNSFKDPNNEFFSIGQ--------RISEFTFWGGLKVMLYILMPKLMK 238
            ...|..|:||:.|||::..|.::..:|..|..|        ||.:      |.|:.|  :|||:.
  Fly   189 CDLYNTDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIID------LFVIFY--LPKLVP 245

  Fly   239 ALRVPVMDMNNVDYFKKLVFGAMKYRKEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAE 303
            .||..:....:.::.::::...::.|:....:|.|:|.:|:..::          |:..||||:.
  Fly   246 LLRPKLFTEPHAEFLRRVIQLVIEERERGGDLRNDLIEMLLTLKK----------EADLQQDKSH 300

  Fly   304 F--NDDDLLAQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKP---LDY 363
            |  :.|.|.||...|..||.||.:..:||..|||...|.:|.:|..||   :|.....|   |.|
  Fly   301 FTHHRDFLAAQAASFEVAGIETCSASMSFALYELAKQPLMQSRLRREI---REAFASNPNGRLTY 362

  Fly   364 DTLMGMKYLNCVVSESLRKWPPAFIVDRMC----GSDFQLKDEEGEVVVNLREDDLVHINVGALH 424
            :.:..|::|:.||.|:|||:|...:::|.|    ...|.......|...  |....|.|:..|:|
  Fly   363 EAVARMEFLDMVVEETLRKYPIVPLLERECTPINKKRFYSLRPHAECYT--RRGMPVFISNLAIH 425

  Fly   425 HDPDNFPEPEQFRPERFDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKP 489
            |||..:|:|::|.||||...:|......:|:|||.|.|:|||.::.|:::|..:...:.::.::.
  Fly   426 HDPKYWPDPDRFDPERFSAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEI 490

  Fly   490 TDRTPADMMSSISGFRLLPRE 510
            .||| .:.:...:.|.||..|
  Fly   491 CDRT-VERIQFDAKFALLASE 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	146/503 (29%)
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	137/478 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461051
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900