DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9c1 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	512	Identity:	148/512 - (28%)
Similarity:	256/512 - (50%)	Gaps:	66/512 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VELSIFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKH--SIDLHLR 66
            |..::.|..|.|||. :.|:..|:|.|.|:...:|:|.:|.        ..||.|.  :.|:...
Zfish     9 VTWTLVVLVITLLLI-YGVWPHGFFKKLGIPGPRPLPFVGT--------ALSYSKGICNFDIECS 64

  Fly    67 LKQHKVYGVFNLRDPLYYLSDPELIRQVGIKN-FDTFTNHRKGITEGFNDTSV--ISKSLLSLRD 128
            .|..||:|:::.|.||..::|.|:|:.:.:|: :.||||.|     ..|...|  .:..:..::|
Zfish    65 KKYGKVWGIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNRR-----NMNPDLVGPFADGITLVKD 124

  Fly   129 RRWKQMRSTLTPTFTSLKIRQMFELI------HFCNVEAVDFVQRQLDAGTSELELKDFFTRYTN 187
            .||:::||:|:|.|||.:::::|.:.      ...|:|..|        ....|::||....|:.
Zfish   125 ERWRRIRSSLSPYFTSGRLKEIFPIAMTHADRFIKNMEKKD--------PNLPLKIKDVVAPYSL 181

  Fly   188 DVIATAAFGIQVNSFKDPNNEFFSIGQRISEFTFWGGLKVMLYIL-----MPKLMKALRVPVMDM 247
            ||:|:::|.:..:|..:|::.|.:   .|..|.....|..:..:|     ...|:..:.:.|...
Zfish   182 DVVASSSFSVDFDSINNPDDPFVT---SIKSFFNINPLSPLFLLLAFCPSAANLLAKMGISVFSR 243

  Fly   248 NNVDYFKKLVFGAMKYRKEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQ 312
            :..|::.| ....:|....:|..|.|.:.|::  |.|...:|  ..::|::|......|.::|:|
Zfish   244 STTDFYYK-ALRKIKDEHNESNGRVDFLKLMI--QNQIPDDQ--VKDTASEQPVKGLTDHEILSQ 303

  Fly   313 CLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEK------PLDYDTLMGMKY 371
            ..:|...|:||.:|.||:..|.|..||:..|||:.||        :|      |:.||.||.|.|
Zfish   304 SFIFILGGYETTSTTLSYLLYNLATNPDCLEKLVEEI--------DKNFPLDIPITYDALMRMDY 360

  Fly   372 LNCVVSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQF 436
            |...:.||:|.:|....::|:|....::..      :.:.::.||.|.:..|..|||.:..|.:|
Zfish   361 LEMAIHESMRVFPAGPRLERVCKKTVEING------ITIPKNTLVGIPLYVLSRDPDLWESPNEF 419

  Fly   437 RPERFDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRT 493
            :||||..|.|.||.|..::|||:|.|:|||.|.|||.:|.|:.:|:.:|.::....|
Zfish   420 KPERFSPESKTEINQCAFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKYTVETCKET 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	137/479 (29%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	137/482 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3329
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.800