DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and Cyp4a8

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_038965258.1	Gene:	Cyp4a8 / 266674	RGDID:	628846	Length:	510	Species:	Rattus norvegicus

Alignment Length:	574	Identity:	136/574 - (23%)
Similarity:	224/574 - (39%)	Gaps:	147/574 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FVELSIFVAFIGLLLYKWSVYTFGYFSKRGV---AHEKPIPLLGNIP--W------SVLMGKESY 56
            |::::..:..: |||:|.:.:   |..:|.:   ..:.|.|     |  |      |.|:.:|..
  Rat    18 FLQIATVLTVL-LLLFKTAQF---YLHRRWLLRATQQFPSP-----PSHWFFGHKLSFLVDQEFQ 73

  Fly    57 IKHSIDLHLRLKQHK------VYGVFNLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEGFND 115
                 |:..|:|...      ::| .|:|..:|   ||:.::.: :...|..::|.......:
  Rat    74 -----DILTRVKNFPSACPQWLWG-SNVRIQVY---DPDYMKLI-LGRSDPKSHHSYRFLAPW-- 126

  Fly   116 TSVISKSLLSLRDRRWKQMRSTLTPTFTSLKIRQMFELIHFCNVE-----AVDFVQRQLD----- 170
               |...||.|..:.|.|.|..|||.|            |:..::     ..|.|:..||
  Rat   127 ---IGYGLLLLNGQTWFQHRRMLTPAF------------HYDTLKPYVGIMADSVRIMLDKWEQI 176

  Fly   171 -AGTSELELKDFFTRYTNDVIATAAFGIQVNSFKDPNNEFFSIGQRISEFTFWGGLKVMLYILMP 234
             ...|.||:....|..|.|.|...||. |..|                             :.:.
  Rat   177 VGQDSTLEIFQHITLMTLDTIMKCAFS-QEGS-----------------------------VQLD 211

  Fly   235 KLMKALRVPVMDMNNVDYFK------------KLVFGAMKYRKEQSIVRPDMIHLLMEAQRQFKA 287
            :..|:....|.|:||:.:|:            .|.....|.|....:.......::...:.|.:.
  Rat   212 RKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHTDQVIKSRKAQLQD 276

  Fly   288 EQEGSAESAAQQDKAEF---------------NDDDLLAQCLLFFSAGFETVATCLSFTSYELMM 337
            |:|  .:...|:.:.:|               :|.||.|:...|...|.:|.|:.:|:..|.|..
  Rat   277 EEE--LQKVKQKRRLDFLDILLFARIENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALAT 339

  Fly   338 NPEVQEKLLAEILAVKEQLGE-KPLDYDTLMGMKYLNCVVSESLRKWPPAFIVDRMCGSDFQLKD 401
            |||.|:....||.::   ||: ..:.:|.|..|.|....:.|:||.:||...|.||..:.....|
  Rat   340 NPEHQQGCRKEIQSL---LGDGASITWDDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPD 401

  Fly   402 EEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEE---HKHEIRQFTYLPFGVGQRS 463
            ..     :|.:...|.::...|||:|..:|.||.|.|.||..|   |.|     ::|||..|.|:
  Rat   402 GR-----SLPKGITVMLSFYGLHHNPTVWPNPEVFDPYRFAPESSRHSH-----SFLPFSGGARN 456

  Fly   464 CIGNRLALMEVKSLIFQLVLRYHLKPTDRT------PADMMSSISGFRLLPREL 511
            |||.:.|:.|:|..:...:||:.|.| |.|      |..::.|.:|..|..::|
  Rat   457 CIGKQFAMNELKVAVALTLLRFELLP-DPTRIPIPIPRLVLKSKNGIYLRLKKL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	129/537 (24%)
Cyp4a8	XP_038965258.1	CYP4B-like	72..505	CDD:410771	120/505 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900