DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	464	Identity:	104/464 - (22%)
Similarity:	184/464 - (39%)	Gaps:	74/464 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 GVFNLRDP-----LYYLSDPELIRQVGIKNFDTFTNHRKGITEGFNDTSVISKSLLSLRDRRWKQ 133
            |..|:.:|     :|...||:     ....:|.|...             |.|.||.|...:|.|
  Rat    90 GFLNIYEPDYAKAVYSRGDPK-----AADVYDFFLQW-------------IGKGLLVLDGPKWFQ 136

  Fly   134 MRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGTSELELKDFFT---RYTNDVIATAAF 195
            .|..|||.|....::....:.    .|:...:..:.:...||.:..|.|.   ....|.:....|
  Rat   137 HRKLLTPGFHYDVLKPYVAIF----AESTRMMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTF 197

  Fly   196 GIQVNSFKDPNNEFF--------SIGQRISEFTFWGGLKVMLYILMPKLMKALRVPVMDMNNVDY 252
            |...:.....:|.::        .:.|||..|.:...   .:|.|.|...:.||...:..::.|.
  Rat   198 GKGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHND---FIYWLTPHGRRFLRACKIAHDHTDE 259

  Fly   253 FKKLVFGAMKYRKEQSIVRP----DMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQC 313
            ..:....|::..||:..::.    |.:.:|:..:     ::.|          .:.:|.:|.|:.
  Rat   260 VIRQRKAALQDEKERKKIQQRRHLDFLDILLGVR-----DESG----------IKLSDAELRAEV 309

  Fly   314 LLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEK-PLDYDTLMGMKYLNCVVS 377
            ..|...|.:|..:.:|:..|.:.:.||.|:....|:..:   ||:: ...:|.|..|.||...:.
  Rat   310 DTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGI---LGDQDSFQWDDLAKMTYLTMCMK 371

  Fly   378 ESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFD 442
            |..|.:||...|.|.........|..     :|....|:.:::.|||.:...:|:||.|.|.||.
  Rat   372 ECFRLYPPVPQVYRQLNKPVTFVDGR-----SLPAGSLISLHIYALHRNSTVWPDPEVFDPLRFS 431

  Fly   443 EEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYH--LKPTD---RTPADMMSSIS 502
            .|:......|.::||..|.|:|||.:.|:.|:|.:....:||:.  |.|:.   :.|..::.|.:
  Rat   432 PENAAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSLDPSKMPIKVPQLILRSKN 496

  Fly   503 GFRLLPREL 511
            |..|..:.|
  Rat   497 GIHLYLKPL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	104/464 (22%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	102/457 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900