DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and cyp-25A4

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_497779.1	Gene:	cyp-25A4 / 183248	WormBaseID:	WBGene00007967	Length:	501	Species:	Caenorhabditis elegans

Alignment Length:	551	Identity:	143/551 - (25%)
Similarity:	245/551 - (44%)	Gaps:	106/551 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VFVELSIFVAFIGLLLYK-WSVYT-FGYFSKRGVAHEKPIP----LLGNIPWSVLMGKESYIKHS 60
            :.:..:||...|..:.|. |..:. |...|..|:    |.|    |.||:  :::..:.|.:.::
Worm     3 ILIISTIFFTIITFISYSIWRRHAIFKLRSSIGI----PGPPVHWLWGNL--NIIKDRVSRLGYN 61

  Fly    61 IDLHLRLKQHKVYGVFNLRDPLYYL----------SDPELIRQVGIKNFDTFTNHRKGITEGFND 115
            .........|..||      |::.|          |:.|.|:::.|:||..|::.......|.|.
Worm    62 DTTQWHPTLHTKYG------PIFGLYCGTQLHITVSEEEDIKEIFIQNFSNFSDRMTPDIFGMNQ 120

  Fly   116 TSVISKSLL-SLRDRRWKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGTSELELK 179
               :::||| :.....||..||.:.|.|::.|::.|.|.:    |..:|.....|...:|..:..
Worm   121 ---LNQSLLQNTYATGWKHTRSAIAPIFSTGKMKAMHETL----VSKIDIFLEVLKEKSSSGQKW 178

  Fly   180 DFFTRYTN---DVIATAAFGIQVNSFKDPNNEFFSIGQRISEFTFWGGLKVM------LYILMPK 235
            |.|..:.:   |:|...||.|..|..:|..:.|:     :....|.|.:.:.      :.:::|:
Worm   179 DIFENFQSLSLDIIGKCAFAIDSNCQRDRTDLFY-----VQARKFVGAVDLKKSWILPVSLILPE 238

  Fly   236 L------------MKALRVPVMDMNNVDYFKKLVFGAMKYRKEQSIVRPDMIHLLMEAQRQFKAE 288
            |            :.|..:|:: ...||.:.:...|      |......|:::||:..:...|..
Worm   239 LSWLWRFLYKFSDLSAAELPLV-KGLVDLYDRRRAG------EGGNDSTDLLNLLIRRETIGKMT 296

  Fly   289 QEGSAESAAQQDKAEFNDDDLLAQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVK 353
            |.                 :::..|..|..||:||.:|.:.|::|.|...|.||:||..||...|
Worm   297 QR-----------------EVIENCFAFLIAGYETTSTAMMFSAYLLAEYPIVQQKLYEEIKKTK 344

  Fly   354 EQLGEKPLDYDTLMGMKYLNCVVSESLRKWPP-AFIVDRMCGSDFQLKDEEGEVVVNLREDDLVH 417
            |..|   |:||::..||||:||..||||.:|| ....:|:|.:|..::   |::   ..||..:.
Worm   345 ENAG---LNYDSIHNMKYLDCVYKESLRFYPPTTHFTNRVCLNDMTIR---GQI---YPEDSTLK 400

  Fly   418 INVGALHHDPDNFPEPEQFRPERFD--EEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQ 480
            :....:|.:|.|:..|::|:||||:  ||....::   ::|||||.|.|:|.|.|.||.|:.|.:
Worm   401 VQPYTIHRNPANWESPDEFQPERFENWEEKSSSLK---WIPFGVGPRYCVGMRFAEMEFKTTIAK 462

  Fly   481 LVLRYHLKPTDRTPAD--MMSSISGFRLLPR 509
            |:..:.|   ...|.|  |:...:|....||
Worm   463 LLDTFEL---SLVPGDPPMIPETNGVIFRPR 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	135/514 (26%)
cyp-25A4	NP_497779.1	p450	37..489	CDD:278495	133/510 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166576
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28638
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm4722
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.760