DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and Cyp3a9

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_671739.2	Gene:	Cyp3a9 / 171352	RGDID:	708392	Length:	503	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	164/513 - (31%)
Similarity:	279/513 - (54%)	Gaps:	44/513 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLLYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKHSIDLHLRLKQHKVYGVFNLR 79
            :|||.:..::.|.|.|.|:...||:|.||    ::|..::.:  ...|.:...|..|::|:::.|
  Rat    20 VLLYLYGTHSHGIFKKLGIPGPKPLPFLG----TILAYRKGF--WEFDKYCHKKYGKLWGLYDGR 78

  Fly    80 DPLYYLSDPELIRQVGIKN-FDTFTNHRKGITEGFNDTSVISKSLLSLRDRRWKQMRSTLTPTFT 143
            .|:..::||::|:.|.:|. :.||||.|     .|....::.|::....|..||::|:.|:||||
  Rat    79 QPVLAITDPDIIKTVLVKECYSTFTNRR-----NFGPVGILKKAISISEDEEWKRIRALLSPTFT 138

  Fly   144 SLKIRQMFELIHFCNVEAVDFVQRQLDAGTSE---LELKDFFTRYTNDVIATAAFGIQVNSFKDP 205
            |.|:::||.:|:    :..|.:.|.:..|:.|   ..:||.|..|:.|||...:||:.|:|..:|
  Rat   139 SGKLKEMFPIIN----QYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDVITATSFGVNVDSLNNP 199

  Fly   206 NNEFFSIGQRISEFTFWGG--LKVMLYILMPKLMKALRVPVMDMNNVDYFKKLVFGAMKYR-KEQ 267
            .:.|....:::.:|..:..  |.|.|:..:..|.:||.|.:...:.:|:||..|....:.| ||:
  Rat   200 QDPFVEKIKKLLKFDIFDPLFLSVTLFPFLTPLFEALNVSMFPRDVIDFFKTSVERMKENRMKEK 264

  Fly   268 SIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQCLLFFSAGFETVATCLSFTS 332
            ...|.|.:.|::.:|           .|..:......:|.:::||.::|..||:||.::.|||..
  Rat   265 EKQRMDFLQLMINSQ-----------NSKVKDSHKALSDVEIVAQSVIFIFAGYETTSSALSFVL 318

  Fly   333 YELMMNPEVQEKLLAEILAVKEQLGEKP-LDYDTLMGMKYLNCVVSESLRKWPPAFIVDRMCGSD 396
            |.|.::|::|:||..||.|.   |..|. ..||||:.|:||:.||:|:||.:|.|..::|:|.:|
  Rat   319 YLLAIHPDIQKKLQDEIDAA---LPNKAHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTD 380

  Fly   397 FQLKDEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEEHKHEIRQFTYLPFGVGQ 461
            .::..      |.:.:..:|.|...|||.||..:||||:||||||.::::..|..:.|||||.|.
  Rat   381 VEING------VFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPYMYLPFGNGP 439

  Fly   462 RSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPADMMSSISGFRLLPRELFWCKLESR 519
            |:|||.|.|||.:|..:.:::..:..:|...|...:..|..|. |.|.:....|:.||
  Rat   440 RNCIGMRFALMNMKVALVRVLQNFSFQPCKETQIPLKLSKQGL-LQPEKPLLLKVVSR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	154/484 (32%)
Cyp3a9	NP_671739.2	p450	39..493	CDD:278495	154/489 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm9060
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770