DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and CYP3A4

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens

Alignment Length:	530	Identity:	169/530 - (31%)
Similarity:	279/530 - (52%)	Gaps:	56/530 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VELSIFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKH--SIDLHLR 66
            :|..:.:|...:|||.:..::.|.|.|.|:....|:|.||||        .||.|.  ..|:...
Human     9 METWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI--------LSYHKGFCMFDMECH 65

  Fly    67 LKQHKVYGVFNLRDPLYYLSDPELIRQVGIKN-FDTFTNHRKGITEGFNDTSVISKSLLSL-RDR 129
            .|..||:|.::.:.|:..::||::|:.|.:|. :..|||.|.....||      .||.:|: .|.
Human    66 KKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGF------MKSAISIAEDE 124

  Fly   130 RWKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGTSELELKDFFTRYTNDVIATAA 194
            .||::||.|:|||||.|:::|..:|.......|..::|:.:.| ..:.|||.|..|:.|||.:.:
Human   125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETG-KPVTLKDVFGAYSMDVITSTS 188

  Fly   195 FGIQVNSFKDPNNEFFSIGQRISEFTFWGG--LKVMLYILMPKLMKALRVPVMDMNNVDYFKKLV 257
            ||:.::|..:|.:.|....:::..|.|...  |.:.::..:..:::.|.:.|......::.:|
Human   189 FGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRK-- 251

  Fly   258 FGAMKYRKEQSIV-----RPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQCLLFF 317
              ::|..||..:.     |.|.:.|::::|...:.|..          || .:|.:|:||.::|.
Human   252 --SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESH----------KA-LSDLELVAQSIIFI 303

  Fly   318 SAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKPLDYDTLMGMKYLNCVVSESLRK 382
            .||:||.::.|||..|||..:|:||:||..||.||..  .:.|..|||::.|:||:.||:|:||.
Human   304 FAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP--NKAPPTYDTVLQMEYLDMVVNETLRL 366

  Fly   383 WPPAFIVDRMCGSDFQLKD---EEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEE 444
            :|.|..::|:|..|.::..   .:|.||:         |...|||.||..:.|||:|.||||.::
Human   367 FPIAMRLERVCKKDVEINGMFIPKGVVVM---------IPSYALHRDPKYWTEPEKFLPERFSKK 422

  Fly   445 HKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPADMMSSISGFRLLPR 509
            :|..|..:.|.|||.|.|:|||.|.|||.:|..:.:::..:..||...|...:..|:.|. |.|.
Human   423 NKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGL-LQPE 486

  Fly   510 ELFWCKLESR 519
            :....|:|||
Human   487 KPVVLKVESR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	156/490 (32%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	156/495 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1946
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2940
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm41379
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.900