DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9c1 and Cyp4a14

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_031848.1	Gene:	Cyp4a14 / 13119	MGIID:	1096550	Length:	507	Species:	Mus musculus

Alignment Length:	479	Identity:	115/479 - (24%)
Similarity:	195/479 - (40%)	Gaps:	107/479 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 NLRDPLYYLSDPELIRQVGIKNFDTFTNHRKGITEGFNDTSVISKSLLSLRDRRWKQMRSTLTPT 141
            |:|..||   ||:.::.| :...|.   ...||.:.|  ...|...||.|..::|.|.|..|||.
Mouse    91 NIRVLLY---DPDYVKVV-LGRSDP---KASGIYQFF--APWIGYGLLLLNGKKWFQHRRMLTPA 146

  Fly   142 FTSLKIRQMFELIHFCNVEAVDFV---QRQLDAGTSELELKDFFTRYTNDVIATAAFGIQVNSFK 203
            |....::...:::    .::|:.:   ..:||.....||:....:..|.|.:...||..|.:...
Mouse   147 FHYDILKPYVKIM----ADSVNIMLDKWEKLDGQDHPLEIFHCVSLMTLDTVMKCAFSYQGSVQL 207

  Fly   204 DPNNEFFSIGQRISEFTFWGGLKVMLYILMPKLMKALRVPVMDMNNVDYFK--------KLVF-- 258
            |.|::.::                          ||    |.|:||:.:|:        .:::
Mouse   208 DENSKLYT--------------------------KA----VEDLNNLTFFRLRNAFYKYNIIYNM 242

  Fly   259 -------------------GAMKYRKEQSIVRPDMIHLLMEAQRQFKAEQEGSAE------SAAQ 298
                               |.:|.||.|          |...:...||.::...:      .|..
Mouse   243 SSDGRLSHHACQIAHEHTDGVIKMRKSQ----------LQNEEELQKARKKRHLDFLDILLFARM 297

  Fly   299 QDKAEFNDDDLLAQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGE-KPLD 362
            :|:...:|:||.|:...|...|.:|.|:.:|:..|.|..:||.|::...|:.::   ||: ..:.
Mouse   298 EDRNSLSDEDLRAEVDTFMFEGHDTTASGISWIFYALATHPEHQQRCREEVQSI---LGDGTSVT 359

  Fly   363 YDTLMGMKYLNCVVSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDP 427
            :|.|..|.|....:.|:||.:||...|.|...|.....|..     ::.:.....|::..|||:|
Mouse   360 WDHLGQMPYTTMCIKEALRLYPPVISVSRELSSPVTFPDGR-----SIPKGITATISIYGLHHNP 419

  Fly   428 DNFPEPEQFRPERFDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKP-TD 491
            ..:|.|:.|.|.||..:..|  ....||||..|.|:|||.:.|:.|:|..:...:||:.|.| ..
Mouse   420 RFWPNPKVFDPSRFAPDSSH--HSHAYLPFSGGSRNCIGKQFAMNELKVAVALTLLRFELLPDPT 482

  Fly   492 RTPAD----MMSSISGFRLLPREL 511
            |.|..    ::.|.:|..|..::|
Mouse   483 RIPVPIARLVLKSKNGIHLCLKKL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	115/479 (24%)
Cyp4a14	NP_031848.1	p450	52..501	CDD:278495	113/472 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810