DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9c1 and CYP4F8

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_009184.1	Gene:	CYP4F8 / 11283	HGNCID:	2648	Length:	520	Species:	Homo sapiens

Alignment Length:	501	Identity:	120/501 - (23%)
Similarity:	200/501 - (39%)	Gaps:	138/501 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 PLYYLSDPELIRQVGIKNFDTFTNH--------RKGITEGFNDTSVISKSLLSLRDRRWKQMRST 137
            |:..|..|:::|.| |...|..|:.        :..:.:|.         |||:.| :|:..|..
Human    97 PIINLCHPDIVRSV-INTSDAITDKDIVFYKTLKPWLGDGL---------LLSVGD-KWRHHRRL 150

  Fly   138 LTPTFTSLKIRQMFELIHF-------------CNVEAVDFVQRQLDAGTSELELKDFFTRYTNDV 189
            |||.|            ||             .|:....: ||....|::.|::.:..:..|.|.
Human   151 LTPAF------------HFNILKPYIKIFSKSANIMHAKW-QRLAMEGSTCLDVFEHISLMTLDS 202

  Fly   190 IATAAFGIQVNSFKDP-----------------NNEFFSIGQRISEFTFWGGLKVMLYILMP--- 234
            :....|....|..:.|                 ||:||    |..:|         ||.|.|
Human   203 LQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF----RYKDF---------LYFLTPCGR 254

  Fly   235 KLMKALRVPVMDMNN--------------VDYFKKLVFGAMKYRKEQSIVRPDMIHLLMEAQRQF 285
            :..:|.|: |.|..:              ||.|      .....|.:::   |.|.:|:
Human   255 RFHRACRL-VHDFTDAVIQERRRTLTSQGVDDF------LQAKAKSKTL---DFIDVLL------ 303

  Fly   286 KAEQEGSAESAAQQDK--AEFNDDDLLAQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAE 348
                       ..:||  .|.:|:|:.|:...|...|.:|.|:.||:..|.|..:||.||:...|
Human   304 -----------LSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQE 357

  Fly   349 ILAVKEQLGEKPLDYDTLMGMKYLNCVVSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLRED 413
            :..:.:....|.:::|.|..:.:|...:.||||..||.....|.|..|..|.|..     .:.:.
Human   358 VQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSR-----VIPKG 417

  Fly   414 DLVHINVGALHHDPDNFPEPEQFRPERFDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLI 478
            ::.:||:.|:||:|..:|:||.:.|.|||.|:..:.....::||..|.|:|||.:.|:.|:|.::
Human   418 NVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVL 482

  Fly   479 FQLVLRYHLKPTD----RTPADMMSSISGFRLLPRELFWCKLESRG 520
            ...:||:.:.|..    |||..::.:..|        .|.::|..|
Human   483 ALTLLRFRILPDHREPRRTPEIVLRAEDG--------LWLRVEPLG 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	117/493 (24%)
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	116/475 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810