DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9c1 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_598730.1	Gene:	Cyp4v3 / 102294	MGIID:	2142763	Length:	525	Species:	Mus musculus

Alignment Length:	509	Identity:	116/509 - (22%)
Similarity:	213/509 - (41%)	Gaps:	86/509 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LMGKESYIKHSIDLHLRLKQHKVYGVFNLRD-PL--YYLSDPELIRQVGIKNFDTFTNHRKGITE 111
            |:|...|:|.:   :....|..:|.....|. |:  .::....|:.....:|.:......|.|
Mouse    59 LVGHALYMKPN---NAEFFQQLIYYTEEFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQI-- 118

  Fly   112 GFNDTSVISK--------SLLSLRDRRWKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQ 168
               |.|.:.|        .||:....:|:..|..|||||....:....::::    |..:.:..:
Mouse   119 ---DKSFLYKFLQPWLGLGLLTSTGSKWRTRRKMLTPTFHFTILENFLDVMN----EQANILVNK 176

  Fly   169 LDAGTSELELKDFF--TRYTNDVIATAAFGIQVNSFKDPNNEFFSIGQRISEFTFWGGLKVMLY- 230
            |:...::.....||  |....|:|...|.|..:.:..:.::|:.....|:|:         |:|
Mouse   177 LEKHVNQEAFNCFFYITLCALDIICETAMGKNIGAQSNNDSEYVRTVYRMSD---------MIYR 232

  Fly   231 -ILMPKLMKALRVPVMDMNNVDYFKKLVFGAMKYRKEQSIVRPDMIHLLMEAQRQFKAEQEGSAE 294
             :.||.|...|...|        ||:    ...:::....:.....:::.|..::.|||::.:..
Mouse   233 RMKMPWLWFDLWYLV--------FKE----GRDHKRGLKCLHTFTNNVIAERVKERKAEEDWTGA 285

  Fly   295 -------------------SAAQQDKAEFNDDDLLAQCLLFFSAGFETVATCLSFTSYELMMNPE 340
                               |...::....:.:|:..:...|...|.:|.|..::::.|.|..|||
Mouse   286 GRGPIPSKNKRKAFLDLLLSVTDEEGNRLSQEDIREEVDTFMFEGHDTTAAAINWSLYLLGTNPE 350

  Fly   341 VQEKLLAEILAVKEQLG--EKPLDYDTLMGMKYLNCVVSESLRKWPPAFIVDRMCGSDFQL---K 400
            ||.|:..|:   .|..|  .:|:..:.|..:|||:||:.|:||.:|...:..|....|.::   |
Mouse   351 VQRKVDQEL---DEVFGRSHRPVTLEDLKKLKYLDCVIKETLRVFPSVPLFARSLSEDCEVGGYK 412

  Fly   401 DEEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEEHKHEIRQFTYLPFGVGQRSCI 465
            ..:|...:         |...|||.||..||:||:||||||..|:......:.|:||..|.|:||
Mouse   413 VTKGTEAI---------IIPYALHRDPRYFPDPEEFRPERFFPENSQGRHPYAYVPFSAGPRNCI 468

  Fly   466 GNRLALMEVKSLIFQLVLRYHLKPTDRTPADMMSSISGFRLLPRELFWCKLESR 519
            |.:.|:||.|:::..::.::.::...:  .:.:.......|.|....|.||:.|
Mouse   469 GQKFAVMEEKTILACILRQFWVESNQK--REELGLAGDLILRPNNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	112/502 (22%)
Cyp4v3	NP_598730.1	p450	51..517	CDD:278495	113/504 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810