DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9c1 and CYP3A7-CYP3A51P

DIOPT Version :9

Sequence 1:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001243426.2	Gene:	CYP3A7-CYP3A51P / 100861540	HGNCID:	51504	Length:	535	Species:	Homo sapiens

Alignment Length:	526	Identity:	167/526 - (31%)
Similarity:	275/526 - (52%)	Gaps:	48/526 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VELSIFVAFIGLLLYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKHSIDLHLRLK 68
            ||..:.:|...:|||.:...|.|.|.|.|:....|:|.|||    .|..::.|  .:.|:....|
Human     9 VETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGN----ALSFRKGY--WTFDMECYKK 67

  Fly    69 QHKVYGVFNLRDPLYYLSDPELIRQVGIKN-FDTFTNHRKGITEGFNDTSVISKSLLSL-RDRRW 131
            ..||:|:::.:.|:..::||::|:.|.:|. :..|||.|.....||      .|:.:|: .|..|
Human    68 YRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGF------MKNAISIAEDEEW 126

  Fly   132 KQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGTSELELKDFFTRYTNDVIATAAFG 196
            |::||.|:|||||.|:::|..:|.......|..::|:.:.| ..:.||..|..|:.|||.:.:||
Human   127 KRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETG-KPVTLKHVFGAYSMDVITSTSFG 190

  Fly   197 IQVNSFKDPNNEFFSIGQRISEFT----FWGGLKVMLYILMPKLMKALRVPVMDMNNVDYFKKLV 257
            :.::|..:|.:.|....:::..|.    |...:||..: |.| :::||.:.|.....:.:..|.|
Human   191 VSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPF-LTP-ILEALNITVFPRKVISFLTKSV 253

  Fly   258 FGAMKYR-KEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQCLLFFSAGF 321
            ....:.| ||....|.|.:.|::::|....:|..          || .:|.:|:||.::|..||:
Human   254 KQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETH----------KA-LSDLELMAQSIIFIFAGY 307

  Fly   322 ETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKPLDYDTLMGMKYLNCVVSESLRKWPPA 386
            ||.::.|||..|||..:|:||:|:..||..|..  .:.|..|||::.::||:.||:|:||.:|.|
Human   308 ETTSSVLSFIIYELATHPDVQQKVQKEIDTVLP--NKAPPTYDTVLQLEYLDMVVNETLRLFPVA 370

  Fly   387 FIVDRMCGSDFQLKD---EEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEEHKHE 448
            ..::|:|..|.::..   .:|.||:         |....|||||..:.|||:|.||||.:::|..
Human   371 MRLERVCKKDVEINGMFIPKGVVVM---------IPSYVLHHDPKYWTEPEKFLPERFSKKNKDN 426

  Fly   449 IRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPADMMSSISGFRLLPRELFW 513
            |..:.|.|||.|.|:|||.|.||:.:|..:.:::..:..||...|...:.....|. ||..:...
Human   427 IDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGL-LLTEKPIV 490

  Fly   514 CKLESR 519
            .|.|||
Human   491 LKAESR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	152/486 (31%)
CYP3A7-CYP3A51P	NP_001243426.2	p450	39..492	CDD:278495	152/490 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1946
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2940
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm41379
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.770