DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adck1 and COQ8B

DIOPT Version :9

Sequence 1:	NP_001286851.1	Gene:	Adck1 / 37938	FlyBaseID:	FBgn0035039	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_079152.3	Gene:	COQ8B / 79934	HGNCID:	19041	Length:	544	Species:	Homo sapiens

Alignment Length:	362	Identity:	89/362 - (24%)
Similarity:	166/362 - (45%)	Gaps:	48/362 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 AEKLLQLICINKGVYIKVGQHIGALE--YLLPKEFVQTMKVLHSDAPQNPIEDLYKVIRQDLHCN 142
            ||:::|.:|..:|..:||||.:...:  ::.| :.....:.:...|...|...:.:|:.::|..:
Human   139 AERIVQTLCTVRGAALKVGQMLSIQDNSFISP-QLQHIFERVRQSADFMPRWQMLRVLEEELGRD 202

  Fly   143 PEEIFDSFEREPLGTASLAQVHKARLKTGELVAVKVQHPYVKGNSRVDMK----TMELAVNVLAR 203
            .:....|.|..|...||:.|||:..|:.|..||||:|:|.:..:.:.|::    .::::..:.|.
Human   203 WQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLKMSAALPAG 267

  Fly   204 IFPDFKIHWLVEESKKNLPIELDFLNEGRNAEKVAKQFKKYSWLRVPKIYWKYSSSRVLVMEYLE 268
            :|.:..:..|.:|    |..|.|:..|...|:...:......:.|||.:..:..::|||.|| |.
Human   268 LFAEQSLQALQQE----LAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGME-LA 327

  Fly   269 GGHVTD----LDYIRRNKIDSFAVANRIGQLYSEMIFRTGFVHSDPHPGNILVRRTPENSLEIVL 329
            ||...|    |....||:|     ..::..|....:|...|:.:||:..|.|.   ..:|.::.|
Human   328 GGVPLDQCQGLSQDLRNQI-----CFQLLTLCLRELFEFRFMQTDPNWANFLY---DASSHQVTL 384

  Fly   330 LDHGLYANLTDKFRYDYSNLWLSILKV----DRKAMRQHSEQL----GIKGDLYG---LFACMVT 383
            ||.|    .:.:|..::::.::.::|.    ||..:.|.|..|    |.:...:.   :.|.|:.
Human   385 LDFG----ASREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDLKFLTGFETKAFSDAHVEAVMIL 445

  Fly   384 GRPWETVMQGLTKVKY---SKEEKNTLQNNTSLVLPH 417
            |.|:.|  ||    .|   |.|....:|:...::|.|
Human   446 GEPFAT--QG----PYDFGSGETARRIQDLIPVLLRH 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adck1	NP_001286851.1	ADCK1-like	118..369	CDD:270871	65/266 (24%)
COQ8B	NP_079152.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..86
		KxGQ motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	155..158		2/2 (100%)
		ABC1_ADCK3	175..424	CDD:270872	64/265 (24%)
		AAAS motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	216..219		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810