DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adck1 and COQ8A

DIOPT Version :9

Sequence 1:	NP_001286851.1	Gene:	Adck1 / 37938	FlyBaseID:	FBgn0035039	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_064632.2	Gene:	COQ8A / 56997	HGNCID:	16812	Length:	647	Species:	Homo sapiens

Alignment Length:	481	Identity:	110/481 - (22%)
Similarity:	199/481 - (41%)	Gaps:	85/481 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 IVRLSRSAAAVVDVALTYKRELYYKEWDKETPEYK----AEKSRVHKIAAEKLLQLICINKGVYI 95
            |.||:......|.:......|:..|....|.|..|    .....:.:..||::::.:|..:|..:
Human   211 IGRLANFGGLAVGLGFGALAEVAKKSLRSEDPSGKKAVLGSSPFLSEANAERIVRTLCKVRGAAL 275

  Fly    96 KVGQHIGALE--YLLPKEFVQTMKVLHSDAPQNPIEDLYKVIRQDLHCNPEEIFDSFEREPLGTA 158
            |:||.:...:  ::.| ...:..:.:...|...|::.:.|.:..||..|..:..:.||..|...|
Human   276 KLGQMLSIQDDAFINP-HLAKIFERVRQSADFMPLKQMMKTLNNDLGPNWRDKLEYFEERPFAAA 339

  Fly   159 SLAQVHKARLKTGELVAVKVQHPYVKGNSRVDMKTMELAVNVLARIFPD--FKIHWLVEESKKNL 221
            |:.|||.||:|.|..||:|:|:|.|..:...|:..: :||..::.:.|:  |..| |::..::.|
Human   340 SIGQVHLARMKGGREVAMKIQYPGVAQSINSDVNNL-MAVLNMSNMLPEGLFPEH-LIDVLRREL 402

  Fly   222 PIELDFLNEGRNAEKVAKQFKKYSWLRVPKIYWKYSSSRVLVMEYLEG---GHVTDLDYIRRNKI 283
            .:|.|:..|...|.|.....|.:.:..||:|..:..|..||..|.:.|   .....|....||:|
Human   403 ALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLSQEIRNEI 467

  Fly   284 DSFAVANRIGQLYSEMIFRTGFVHSDPHPGNILVRRTPENSLEIVLLDHGLYANLTDKFRYDYSN 348
                 ...|..|....:|...|:.:||:..|...  .|:.. ::.|||.|    .|.::...:::
Human   468 -----CYNILVLCLRELFEFHFMQTDPNWSNFFY--DPQQH-KVALLDFG----ATREYDRSFTD 520

  Fly   349 LWLSILKV----DRKAMRQHS--------EQLGIKGDLYGLFACMVTG------RPWETVMQGLT 395
            |::.|::.    ||:.:|..|        .::.:..|.: |.|.::.|      .|::...|..|
Human   521 LYIQIIRAAADRDRETVRAKSIEMKFLTGYEVKVMEDAH-LDAILILGEAFASDEPFDFGTQSTT 584

  Fly   396 KVKYSKEEKNTLQNNTSLVLPHISDVLEQVDRQMLLILKTNDLIRGIESTLRTQNRM-TAFWVMS 459
                   ||  :.|...::|.|                   .|:...|.|.....:| .:|.:.|
Human   585 -------EK--IHNLIPVMLRH-------------------RLVPPPEETYSLHRKMGGSFLICS 621

  Fly   460 KC-----C------VQSSYAEQRAKQ 474
            |.     |      ..|:|.:::|:|
Human   622 KLKARFPCKAMFEEAYSNYCKRQAQQ 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adck1	NP_001286851.1	ADCK1-like	118..369	CDD:270871	69/267 (26%)
COQ8A	NP_064632.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..203
		KxGQ motif. /evidence=ECO:0000269\|PubMed:25498144	276..279		1/2 (50%)
		ABC1_ADCK3	295..545	CDD:270872	69/263 (26%)
		AAAS motif. /evidence=ECO:0000269\|PubMed:25498144	337..340		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910