DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adck1 and coq8aa

DIOPT Version :9

Sequence 1:	NP_001286851.1	Gene:	Adck1 / 37938	FlyBaseID:	FBgn0035039	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001002728.2	Gene:	coq8aa / 437001	ZFINID:	ZDB-GENE-040718-487	Length:	619	Species:	Danio rerio

Alignment Length:	374	Identity:	87/374 - (23%)
Similarity:	165/374 - (44%)	Gaps:	61/374 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LRRVLGYG--VVGAGLAS----AGWSLHTNDYDPNSLGIVRLSRSAAAVVDVALTYKRELYYKEW 61
            |.|:..:|  .||.|:.:    |..||.:.|.:.|.          .||:|
Zfish   179 LGRLANFGGLAVGLGIGALAEVAKKSLRSEDKNGNK----------KAVLD-------------- 219

  Fly    62 DKETPEYKAEKSRVHKIAAEKLLQLICINKGVYIKVGQHIGALE--YLLPKEFVQTMKVLHSDAP 124
               :..:.:|.:      ||::::.:|..:|..:|:||.:...:  ::.| :..:..:.:...|.
Zfish   220 ---SSPFLSEAN------AERIVRTLCKVRGAALKLGQMLSIQDDAFINP-QLAKIFERVRQSAD 274

  Fly   125 QNPIEDLYKVIRQDLHCNPEEIFDSFEREPLGTASLAQVHKARLKTGELVAVKVQHPYVKGNSRV 189
            ..||:.:.|.:..||..|..:..:.||..|...||:.|||.||:|.|..||:|:|:|.|..:...
Zfish   275 FMPIKQMTKALSNDLGPNWRDKLEMFEERPFAAASIGQVHLARMKDGREVAMKIQYPGVAQSINS 339

  Fly   190 DMKTMELAVNVLARIFPD--FKIHWLVEESKKNLPIELDFLNEGRNAEKVAKQFKKYSWLRVPKI 252
            |:..: :.|..::...|:  |..| |::..::.|.:|.|::.|.:.|.|..:..|.:.:..||.:
Zfish   340 DVNNL-MTVLSMSNALPEGLFPEH-LIDVMRRELALECDYIREAKCARKFKELLKDHPFFYVPDV 402

  Fly   253 YWKYSSSRVLVMEYLEGGHVTDLDYIR---RNKIDSFAVANRIGQLYSEMIFRTGFVHSDPHPGN 314
            ..:.||..||..|.:.|..:...:.:.   :|:|     ...|..|....:|...::.:||:..|
Zfish   403 ISELSSQHVLTTELVPGFPLDQAEALTQELKNEI-----CKNILNLCLRELFEFRYMQTDPNWSN 462

  Fly   315 ILVRRTPENSLEIVLLDHGLYANLTDKFRYDYSNLWLSILKVDRKAMRQ 363
            ...  .|:.. .:.|||.|    .|..|...::::::.|:|......|:
Zfish   463 FFY--DPQTH-RVALLDFG----ATRGFDESFTDVYIEIIKAAADGNRE 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adck1	NP_001286851.1	ADCK1-like	118..369	CDD:270871	64/251 (25%)
coq8aa	NP_001002728.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..171
		AarF	172..603	CDD:223733	87/374 (23%)
		KxGQ motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	245..248		1/2 (50%)
		ABC1_ADCK3	264..514	CDD:270872	64/255 (25%)
		AAAS motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	306..309		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810