DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adck1 and Adck5

DIOPT Version :9

Sequence 1:	NP_001286851.1	Gene:	Adck1 / 37938	FlyBaseID:	FBgn0035039	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_766548.2	Gene:	Adck5 / 268822	MGIID:	2679274	Length:	582	Species:	Mus musculus

Alignment Length:	542	Identity:	176/542 - (32%)
Similarity:	282/542 - (52%)	Gaps:	51/542 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLRRVLGYGVVGAGLASAGWSLHTNDYDPNSL-----GIVRLSRSAAAVVDVALTYKRELYYKE 60
            :|.||.|...|||.......:.......:...|     ||.|..||....:.::..|
Mouse    45 LLWRRALSATVVGTPFLLGAYYFMAEASERRKLRLAVDGIGRFGRSVKIGLFISTDY-------- 101

  Fly    61 W----------DKETPEYKAEKSRVHKIAAEKLLQLICINKGVYIKVGQHIGALEYLLPKEFVQT 115
            |          ::.:|:|....|..|:.||:.|:.....|.|:|:|:||.:.:..:|||.|::||
Mouse   102 WWCTNVVLRGVEENSPKYVEIMSACHQRAADTLVAGAIRNGGLYVKLGQGLCSFNHLLPTEYIQT 166

  Fly   116 MKVLHSDAPQNPIEDLYKVIRQDLHCNPEEIFDSFEREPLGTASLAQVHKARLKTGELVAVKVQH 180
            ::||...|......::.::..:|....|.|:|..|:.||:..|||||||:|:|..|..||||||:
Mouse   167 LRVLEDKALTRGFREVDELFLEDFQALPNELFQEFDYEPMAAASLAQVHRAKLHDGTDVAVKVQY 231

  Fly   181 PYVKGNSRVDMKTMELAVNVLARIFPDFKIHWLVEESKKNLPIELDFLNEGRNAEKVAKQFKKYS 245
            ..::.....|::|:||.:.::..:.|.|...|::::.|..|..||||.|||||||:.|::.|.:.
Mouse   232 IDLRDRFDGDVQTLELLLRLVELMHPSFGFSWVLQDLKGTLVQELDFENEGRNAERCAQELKHFH 296

  Fly   246 WLRVPKIYWKYSSSRVLVMEYLEGGHVTDLDYIRRNKIDSFAVANRIGQLYSEMIFRTGFVHSDP 310
            ::.:|:::|..||.|||..::..|..|.|::.|:...:....||.::.|.::|.||.|||:||||
Mouse   297 YVVIPRVHWDRSSKRVLTADFCNGCKVNDMEGIKSQGLAVQDVAKKLIQTFAEQIFHTGFIHSDP 361

  Fly   311 HPGNILVRRTPENSLEIVLLDHGLYANLTDKFRYDYSNLWLSILKVDRKAMRQHSEQLGIKGDLY 375
            ||||:|||:.|:...|:||||||||..|.:|.|.....||.:|:..|..||::|:..||::.  |
Mouse   362 HPGNVLVRKGPDGKAELVLLDHGLYQFLDEKDRSSLCQLWRAIILRDNAAMKKHAAALGVQD--Y 424

  Fly   376 GLFACMVTGRP------WETVMQGLTKVKYSKEEKNTLQNNTSLVLPHISDVLEQVDRQMLLILK 434
            .||:.::..||      |.:.:       .|:||...:|:........|.:||:.:.|.|||:|:
Mouse   425 MLFSEVLMQRPVRLGQLWGSHL-------ISREEAAYMQDMAREHFDGIMEVLKALPRPMLLVLR 482

  Fly   435 TNDLIRGIESTLRTQNRMTAFWVMSKCCVQS-SYAEQRAKQSDSGSS-----RILW----LRVRE 489
            ..:.:|.|.|.|.|.  :..:::|:|..|.. |.....|.|...|||     ::||    ..:..
Mouse   483 NINTVRAINSNLGTP--VDRYFLMAKSAVWGWSRLVGAAYQGIYGSSLLRHIKVLWEALKFEMAL 545

  Fly   490 RWELFKLNCYYLYLG-LINFGF 510
            |.|:..:....|.|. |:..||
Mouse   546 RLEILAMRLTALMLRVLVRLGF 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adck1	NP_001286851.1	ADCK1-like	118..369	CDD:270871	99/250 (40%)
Adck5	NP_766548.2	AarF	78..568	CDD:223733	168/509 (33%)
Adck5	NP_766548.2	ADCK1-like	169..420	CDD:270871	99/250 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D350846at33208
OrthoFinder	1	1.000	-	-		FOG0000919
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100510
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720