DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adck1 and AgaP_AGAP012287

DIOPT Version :9

Sequence 1:	NP_001286851.1	Gene:	Adck1 / 37938	FlyBaseID:	FBgn0035039	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	XP_320250.2	Gene:	AgaP_AGAP012287 / 1280403	VectorBaseID:	AGAP012287	Length:	518	Species:	Anopheles gambiae

Alignment Length:	519	Identity:	331/519 - (63%)
Similarity:	410/519 - (78%)	Gaps:	4/519 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLRRVLGYGVVGAGLASAGWSLHTNDYDPNSLGIVRLSRSAAAVVDVALTYKRELYYKEW-DKE 64
            |..||.|.|||||:.:...|.|||.||||.||:|||||.|:.|.|.|:|.||:..||.:|| ||:
Mosquito     1 MSFRRALKYGVVGSAVLGTGLSLHANDYDINSVGIVRLGRAGATVFDIATTYQANLYSREWTDKK 65

  Fly    65 TPEYKAEKSRVHKIAAEKLLQLICINKGVYIKVGQHIGALEYLLPKEFVQTMKVLHSDAPQNPIE 129
            :.||...||..|:.|||:||:|...|:||||||||||||||||||.|:|.|||||||:|||||:|
Mosquito    66 SAEYLKVKSDTHRAAAERLLELCRTNRGVYIKVGQHIGALEYLLPAEYVSTMKVLHSNAPQNPVE 130

  Fly   130 DLYKVIRQDLHCNPEEIFDSFEREPLGTASLAQVHKARLKTGELVAVKVQHPYVKGNSRVDMKTM 194
            |||:||||||...|.::|:||:.||||||||||||:|.||.|..||||||||||||||.||:|||
Mosquito   131 DLYRVIRQDLRVEPSDLFESFDPEPLGTASLAQVHRATLKDGREVAVKVQHPYVKGNSIVDIKTM 195

  Fly   195 ELAVNVLARIFPDFKIHWLVEESKKNLPIELDFLNEGRNAEKVAKQFKKYSWLRVPKIYWKYSSS 259
            |:.|.::|..|||||..|||:|||:|||:||||.|||||||||.:.|:.|.||::|.:.|:|::.
Mosquito   196 EVLVKLVAWTFPDFKFQWLVDESKRNLPMELDFANEGRNAEKVREMFRHYRWLKIPGVIWEYTTP 260

  Fly   260 RVLVMEYLEGGHVTDLDYIRRNKIDSFAVANRIGQLYSEMIFRTGFVHSDPHPGNILVRRTPEN- 323
            |||:|||.:||.|.||:||:|.|:|.:.:||:||||||.|||..||||||||||||||||..:|
Mosquito   261 RVLMMEYTKGGQVNDLEYIQREKLDPYDIANKIGQLYSNMIFLKGFVHSDPHPGNILVRRGEQNG 325

  Fly   324 SLEIVLLDHGLYANLTDKFRYDYSNLWLSILKVDRKAMRQHSEQLGIKGDLYGLFACMVTGRPWE 388
            ..|||||||||||:||:||||:||.||||||:||::.|:::::.||::|.::||||||||||||.
Mosquito   326 GTEIVLLDHGLYADLTEKFRYNYSKLWLSILRVDQEGMKKYAQALGVEGSMWGLFACMVTGRPWN 390

  Fly   389 TVMQGLTKVKYSKEEKNTLQNNTSLVLPHISDVLEQVDRQMLLILKTNDLIRGIESTLRTQNRMT 453
            :|:.|:.|||....||..:||...|||||||||||:|||||||:|||||||||||:|||||||||
Mosquito   391 SVIHGVDKVKQDDAEKEMIQNEGKLVLPHISDVLEKVDRQMLLVLKTNDLIRGIETTLRTQNRMT 455

  Fly   454 AFWVMSKCCVQSSYAEQRAKQSDSGSSRILWLRVRERWELFKLNCYYLYLGLINFGFLEALKQV 517
            ||||||||||:|..:::.....|:.|.  |...:||:|.:.|||.||||.||::...|.|||.:
Mosquito   456 AFWVMSKCCVKSIGSQEYLTAGDTWSK--LTTCLREQWCILKLNLYYLYRGLVSLHLLSALKMI 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adck1	NP_001286851.1	ADCK1-like	118..369	CDD:270871	167/251 (67%)
AgaP_AGAP012287	XP_320250.2	AarF	78..>371	CDD:223733	197/292 (67%)
AgaP_AGAP012287	XP_320250.2	ADCK1-like	119..371	CDD:270871	167/251 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	345	1.000	Domainoid score	I2870
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6493
Inparanoid	1	1.050	678	1.000	Inparanoid score	I1968
OMA	1	1.010	-	-		QHG57752
OrthoDB	1	1.010	-	-		D350846at33208
OrthoFinder	1	1.000	-	-		FOG0000919
OrthoInspector	1	1.000	-	-		oto109889
Panther	1	1.100	-	-	LDO	PTHR43173
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3709
TreeFam	1	0.960	-	-
	13	12.940