Protein Alignment CG4707 and REST

DIOPT Version :10

• Sequence 1: NP_611944.1
• Gene: CG4707 / 37935
• FlyBaseID: FBgn0035036
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_005603.3
• Gene: REST / 5978
• HGNCID: 9966
• Length: 1097
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 126/570 - (22%)
• Similarity: 207/570 - (36%)
• Gaps: 149/570 - (26%)

  Fly   118 EVNELEPLPKVELLEDPVKTEIRTAPKRLGVPNEGSPHSKRRIKNELPVDSDSDAPLADFLNSDS 182
            ::.:|..|.|.||          .||:.:.:.|             :.:..:.:....|:|..:.
Human    29 DMYDLHDLSKAEL----------AAPQLIMLAN-------------VALTGEVNGSCCDYLVGEE 70

  Fly   183 KRSS----VGPAKNSEANKGRQLRRSAR-RGRPPKAKPESAPSPKKELDSEDGEENARDNN-DME 241
            ::.:    ||....|::.:|..|..||. :|.|                  .|.||....: ::.
Human    71 RQMAELMPVGDNNFSDSEEGEGLEESADIKGEP------------------HGLENMELRSLELS 117

  Fly   242 FVAPEAVLGTDDSSSSSSESSG-EDSDHSLPDIEPEERYAEIPKRVVVKPKKYRKREKPLVPPVR 305
            .|.|:.|.          |:|| .|...|..|:.||...||        .|....:.||
Human   118 VVEPQPVF----------EASGAPDIYSSNKDLPPETPGAE--------DKGKSSKTKP------ 158

  Fly   306 LSREEIERRKLQQDEYDEIILQFFKKFPCSLCNLLVQNFADMRRHQRVSHNIESGYIECCGRKFH 370
                                      |.|..|....::......|.|| |:.:..::|....|..
Human   159 --------------------------FRCKPCQYEAESEEQFVHHIRV-HSAKKFFVEESAEKQA 196

  Fly   371 LRK----ALAEHVLVHKNPDHFMCSQCGRVFQDSRALEVHEQTHTNPEVKAEPKEKRIYQCEKCP 431
            ..:    :.||.....|.|  ..|.:||  :..:|  ..|...|.....:|...| |:|:|..|
Human   197 KARESGSSTAEEGDFSKGP--IRCDRCG--YNTNR--YDHYTAHLKHHTRAGDNE-RVYKCIIC- 253

  Fly   432 KSFTTKAAMEYH---DVSKHVPKSEFKYSCPECNKKIPTERKLKEHLRYMHDPEAAIICDKCGKT 493
             ::||  ..|||   .:..|.|:.  .|:|.:||.....:....:|:| .|..|....|:.|..:
Human   254 -TYTT--VSEYHWRKHLRNHFPRK--VYTCGKCNYFSDRKNNYVQHVR-THTGERPYKCELCPYS 312

  Fly   494 LRSQTNLKKHHELEHSEKPRPKPDPVQCEICGTWLRHLSGLKQHMKTVHEPPGDEHRCHICNKTS 558
            ...:|:|.:|......||      |.:|:.|.....:...:.:|.:.||..|...:..|...||:
Human   313 SSQKTHLTRHMRTHSGEK------PFKCDQCSYVASNQHEVTRHARQVHNGPKPLNCPHCDYKTA 371

  Fly   559 TNSRALKRHIYHNHLCERKFKCGMCEKAFKRPQDLREH-TSTHTGEVLYTCPNCPMTFFSNANMY 622
            ..|. .|:|: ..|:..|:|.|.:|:.|..:..:|:.| .|.|.     ||||..|. .|...:.
Human   372 DRSN-FKKHV-ELHVNPRQFNCPVCDYAASKKCNLQYHFKSKHP-----TCPNKTMD-VSKVKLK 428

  Fly   623 KHRQRLHRAEWEADRKKPLPPNIMKISQGATTAMKKRQTSGALFPQSEQK 672
            |.::|      |||    ||.||    ....|.:::.:..|.:..:..:|
Human   429 KTKKR------EAD----LPDNI----TNEKTEIEQTKIKGDVAGKKNEK 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4707	NP_611944.1	zf-AD	3..77	CDD:462262
		C2H2 Zn finger	334..355	CDD:275368	5/20 (25%)
		LIM	<361..407	CDD:413332	10/49 (20%)
		C2H2 Zn finger	365..382	CDD:275368	3/20 (15%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		C2H2 Zn finger	427..443	CDD:275368	5/15 (33%)
		COG5236	<455..>574	CDD:227561	29/118 (25%)
		C2H2 Zn finger	458..476	CDD:275368	4/17 (24%)
		C2H2 Zn finger	487..507	CDD:275368	5/19 (26%)
		C2H2 Zn finger	521..540	CDD:275368	3/18 (17%)
		C2H2 Zn finger	551..572	CDD:275368	6/20 (30%)
		C2H2 Zn finger	580..600	CDD:275368	6/20 (30%)
		C2H2 Zn finger	608..629	CDD:275368	7/20 (35%)
REST	NP_005603.3	Interaction with SIN3A. /evidence=ECO:0000269|PubMed:10734093	32..122		23/130 (18%)
		Interaction with SIN3B. /evidence=ECO:0000269|PubMed:16288918	43..57		3/26 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	83..103		6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	127..159		12/71 (17%)
		Interaction with ZFP90. /evidence=ECO:0000269|PubMed:21284946	145..418		78/340 (23%)
		Required for binding to the neuron-restrictive silencer element. /evidence=ECO:0000250|UniProtKB:Q8VIG1	201..212		2/10 (20%)
		C2H2 Zn finger	218..238	CDD:275368	6/23 (26%)
		C2H2 Zn finger	250..270	CDD:275368	7/23 (30%)
		C2H2 Zn finger	278..298	CDD:275368	5/20 (25%)
		zf-H2C2_2	290..315	CDD:463886	6/25 (24%)
		zf-H2C2_5	304..328	CDD:404746	5/23 (22%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		zf-H2C2_2	318..343	CDD:463886	7/30 (23%)
		C2H2 Zn finger	334..355	CDD:275368	3/20 (15%)
		C2H2 Zn finger	363..383	CDD:275368	6/21 (29%)
		zf-H2C2_5	363..383	CDD:404746	6/21 (29%)
		C2H2 Zn finger	391..407	CDD:275368	4/15 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..642		2/13 (15%)
		PRK10263	<599..>767	CDD:236669
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	774..837
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	853..938
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	961..1049
		Interaction with RCOR1. /evidence=ECO:0000269|PubMed:10449787	1009..1087