Protein Alignment CG4707 and ZNF407

DIOPT Version :10

• Sequence 1: NP_611944.1
• Gene: CG4707 / 37935
• FlyBaseID: FBgn0035036
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_060227.2
• Gene: ZNF407 / 55628
• HGNCID: 19904
• Length: 2248
• Species: Homo sapiens
• Alignment Length: 796
• Identity: 164/796 - (20%)
• Similarity: 269/796 - (33%)
• Gaps: 270/796 - (33%)

  Fly    61 EEFHQRVS----CLHRQRSSDSKSEPIEFCGQTEEAIINPLYSVELDALAEAFFAPSEVKVEVNE 121
            ||.||:.|    .:..|.|...||.....|     :|:|.  :..|| :::...|...|:||..|
Human  1098 EEEHQQNSEEFQIISGQPSDTLKSRNAADC-----SILNE--NTNLD-MSKVLCAADSVEVETEE 1154

  Fly   122 LEPLPKVELLED----------PVKTEIRTAPKRLGV---PNEGSPHSKRRIKNELPVDSDSDAP 173
                 :....||          |||.::|...:.:.:   .|.|||   .|.:||   :|.|.|
Human  1155 -----ESNFNEDHSFCETFQQAPVKDKVRKPEEMMSLTMSSNYGSP---SRFQNE---NSGSSA- 1207

  Fly   174 LADFLNSDSKRSSVGPAKNSE-ANKGRQLR-----RSARRGRPPKAKP------------ESAPS 220
                ||.::.:      ||.| :|...:||     .....|......|            .||.|
Human  1208 ----LNCETAK------KNHEISNDAGELRVHCEGEGGNAGDGGGVVPHRHLCPVTLDGERSAES 1262

  Fly   221 P--------KKELDSEDGEEN--ARDN--NDMEFVAPEAVLGTDDSSSSSS-------ESSGEDS 266
            |        :::.:.|.|.:|  ||.:  .|::.|..:.|||..:...:|.       |..|..|
Human  1263 PVLVVTRITREQGNLESGGQNRVARGHGLEDLKGVQEDPVLGNKEILMNSQHETEFILEEDGPAS 1327

  Fly   267 DHSLPDIEPEERYAEIPKR------------VVVKPKK-------YRKREKPLVPPVRLSR---- 308
            |.::...:..|....|..:            .:::.|.       .:..|..:...||:|.
Human  1328 DSTVESSDVYETIISIDDKGQAMYSFGRFDSSIIRIKNPEDGELIDQSEEGLIATGVRISELPLK 1392

  Fly   309 ---EEIERRKLQQDEYDEIILQFFKKFPCSLCNLLVQNFADMRRHQRVSHNIESGYIEC--CGRK 368
               :.::::|.:.....|     ..:..|..|..|....:.:..|..:.|..:..:..|  ||:.
Human  1393 DCAQGVKKKKSEGSSIGE-----STRIRCDDCGFLADGLSGLNVHIAMKHPTKEKHFHCLLCGKS 1452

  Fly   369 FHLRKALAEH--------------------------------------VLVHKNPDH-------- 387
            |:....|.:|                                      :.:|....|
Human  1453 FYTESNLHQHLASAGHMRNEQASVEELPEGGATFKCVKCTEPFDSEQNLFLHIKGQHEELLREVN 1517

  Fly   388 -------------------FMCSQCGRVFQDSRALE--VHEQTHTNPEVKAEPKEKRI------- 424
                               .:|..||::.:.|.::.  .|.:|||.    ::|.:.:|
Human  1518 KYIVEDTEQINREREENQGNVCKYCGKMCRSSNSMAFLAHIRTHTG----SKPFKCKICHFATAQ 1578

  Fly   425 ----------------YQCEKCPKSFTTKAAMEYHDVSKH---VPKSEFKYSCPECNKKIPTERK 470
                            |:|..|..:|..|..:..|.:.||   .|| |.|::|..|::....:..
Human  1579 LGDARNHVKRHLGMREYKCHVCGVAFVMKKHLNTHLLGKHGVGTPK-ERKFTCHLCDRSFTEKWA 1642

  Fly   471 LKEHLRYMHDPEAAIIC--DKCGKTLRSQTNLKKHHELEHSEKPRPKPDPVQCEICGTWLRHLSG 533
            |..|:: :|..|....|  ..|..:..:.:.:|.|:.....||      ...|::||     .:|
Human  1643 LNNHMK-LHTGEKPFKCTWPTCHYSFLTASAMKDHYRTHTGEK------SFLCDLCG-----FAG 1695

  Fly   534 LKQHMKTVH------EPPGDEHRCHICNKTSTNSRALKRHIYHNHLCERKFKCGMCEKAFKRPQD 592
            ..:|..|.|      |.|   .:|..||..||....|.|| ...|..|:.::|..|:......::
Human  1696 GTRHALTKHRRQHTGEKP---FKCDECNFASTTQSHLTRH-KRVHTGEKPYRCPWCDYRSNCAEN 1756

  Fly   593 LRE---HTSTHTGEVLYTCPNC------PMTFFSNANMYKHRQRLHRAEWEADRKKP----LPPN 644
            :|:   ||..|.|..:|.||.|      |:.|           |.|..|...|.:.|    |...
Human  1757 IRKHILHTGKHEGVKMYNCPKCDYGTNVPVEF-----------RNHLKEQHPDIENPDLAYLHAG 1810

  Fly   645 IMKIS-------QGAT 653
            |:..|       ||||
Human  1811 IVSKSYECRLKGQGAT 1826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4707	NP_611944.1	zf-AD	3..77	CDD:462262	7/19 (37%)
		C2H2 Zn finger	334..355	CDD:275368	4/20 (20%)
		LIM	<361..407	CDD:413332	12/114 (11%)
		C2H2 Zn finger	365..382	CDD:275368	5/54 (9%)
		C2H2 Zn finger	390..410	CDD:275368	5/21 (24%)
		C2H2 Zn finger	427..443	CDD:275368	4/15 (27%)
		COG5236	<455..>574	CDD:227561	31/126 (25%)
		C2H2 Zn finger	458..476	CDD:275368	4/17 (24%)
		C2H2 Zn finger	487..507	CDD:275368	4/21 (19%)
		C2H2 Zn finger	521..540	CDD:275368	5/18 (28%)
		C2H2 Zn finger	551..572	CDD:275368	8/20 (40%)
		C2H2 Zn finger	580..600	CDD:275368	5/22 (23%)
		C2H2 Zn finger	608..629	CDD:275368	6/26 (23%)
ZNF407	NP_060227.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..84
		C2H2 Zn finger	188..208	CDD:275368
		C2H2 Zn finger	217..238	CDD:275368
		C2H2 Zn finger	246..268	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..322
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	494..515
		C2H2 Zn finger	590..614	CDD:275371
		C2H2 Zn finger	617..639	CDD:275371
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	667..700
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	821..847
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	910..962
		C2H2 Zn finger	1416..1445	CDD:275371	5/28 (18%)
		C2H2 Zn finger	1446..1468	CDD:275371	6/21 (29%)
		C2H2 Zn finger	1488..1509	CDD:275371	1/20 (5%)
		C2H2 Zn finger	1539..1561	CDD:275368	5/21 (24%)
		zf-H2C2_2	1557..1578	CDD:463886	6/24 (25%)
		C2H2 Zn finger	1569..1589	CDD:275368	1/19 (5%)
		C2H2 Zn finger	1597..1617	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1630..1650	CDD:275368	4/20 (20%)
		zf-H2C2_2	1642..1669	CDD:463886	6/27 (22%)
		C2H2 Zn finger	1658..1680	CDD:275368	4/21 (19%)
		C2H2 Zn finger	1688..1708	CDD:275368	7/24 (29%)
		zf-H2C2_2	1700..1725	CDD:463886	8/27 (30%)
		zf-H2C2_5	1714..1738	CDD:404746	9/24 (38%)
		C2H2 Zn finger	1716..1736	CDD:275368	8/20 (40%)
		zf-H2C2_2	1728..1753	CDD:463886	7/25 (28%)
		C2H2 Zn finger	1744..1761	CDD:275368	3/16 (19%)